KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix

Somatic mutations in the KRAS oncogene are associated with poor outcomes in locally advanced rectal cancer but the underlying biologic mechanisms are not fully understood. We profiled mRNA in 76 locally advanced rectal adenocarcinomas from patients that were enrolled in a prospective clinical trial...

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Detalles Bibliográficos
Autores principales: Kim, Jin K., Marco, Michael R., Choi, Seo‐Hyun, Qu, Xuan, Chen, Chin‐Tung, Elkabets, Moshe, Fairchild, Lauren, Chow, Oliver, Barriga, Francisco M., Dow, Lukas E., O’Rourke, Kevin, Szeglin, Bryan, Yarilin, Dmitry, Fujisawa, Sho, Manova‐Todorova, Katia, Paty, Philip B., Shia, Jinru, Leslie, Christina, Joshua Smith, J., Lowe, Scott, Pelossof, Raphael, Sanchez‐Vega, Francisco, Garcia‐Aguilar, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486594/
https://www.ncbi.nlm.nih.gov/pubmed/33817986
http://dx.doi.org/10.1002/1878-0261.12960

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