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The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis
The current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake e...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486704/ https://www.ncbi.nlm.nih.gov/pubmed/34415355 http://dx.doi.org/10.1007/s00210-021-02131-0 |
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author | Luo, Junchao Zhang, Yin Zhu, Senbo Tong, Yu Ji, Lichen Zhang, Wei Zhang, Qiong Bi, Qing |
author_facet | Luo, Junchao Zhang, Yin Zhu, Senbo Tong, Yu Ji, Lichen Zhang, Wei Zhang, Qiong Bi, Qing |
author_sort | Luo, Junchao |
collection | PubMed |
description | The current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects. |
format | Online Article Text |
id | pubmed-8486704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-84867042021-10-04 The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis Luo, Junchao Zhang, Yin Zhu, Senbo Tong, Yu Ji, Lichen Zhang, Wei Zhang, Qiong Bi, Qing Naunyn Schmiedebergs Arch Pharmacol Review The current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects. Springer Berlin Heidelberg 2021-08-20 2021 /pmc/articles/PMC8486704/ /pubmed/34415355 http://dx.doi.org/10.1007/s00210-021-02131-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Luo, Junchao Zhang, Yin Zhu, Senbo Tong, Yu Ji, Lichen Zhang, Wei Zhang, Qiong Bi, Qing The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis |
title | The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis |
title_full | The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis |
title_fullStr | The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis |
title_full_unstemmed | The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis |
title_short | The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis |
title_sort | application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486704/ https://www.ncbi.nlm.nih.gov/pubmed/34415355 http://dx.doi.org/10.1007/s00210-021-02131-0 |
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