Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells

Colorectal cancer (CRC) is one of the most deadly and commonly diagnosed tumors worldwide. Several genes are involved in its development and progression. The most frequent mutations concern APC, KRAS, SMAD4, and TP53 genes, suggesting that CRC relies on the concomitant alteration of the related path...

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Detalles Bibliográficos
Autores principales: Sommariva, Sara, Caviglia, Giacomo, Ravera, Silvia, Frassoni, Francesco, Benvenuto, Federico, Tortolina, Lorenzo, Castagnino, Nicoletta, Parodi, Silvio, Piana, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486743/
https://www.ncbi.nlm.nih.gov/pubmed/34599254
http://dx.doi.org/10.1038/s41598-021-99073-7

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