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Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
Carbon nanotubes (CNTs) are cylindrical nanostructures and have unique properties, including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn) as a possible substrate promoting peripheral nerve regeneration with these pro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486759/ https://www.ncbi.nlm.nih.gov/pubmed/34599218 http://dx.doi.org/10.1038/s41598-021-98603-7 |
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author | Kunisaki, Atsushi Kodama, Akira Ishikawa, Masakazu Ueda, Takahiro Lima, Marcio D. Kondo, Takeshi Adachi, Nobuo |
author_facet | Kunisaki, Atsushi Kodama, Akira Ishikawa, Masakazu Ueda, Takahiro Lima, Marcio D. Kondo, Takeshi Adachi, Nobuo |
author_sort | Kunisaki, Atsushi |
collection | PubMed |
description | Carbon nanotubes (CNTs) are cylindrical nanostructures and have unique properties, including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn) as a possible substrate promoting peripheral nerve regeneration with these properties. We bridged a 15 mm rat sciatic nerve defect with five different densities of cYarn. Eight weeks after the surgery, the regenerated axons crossing the CNTs, electromyographical findings, and muscle weight ratio of the lower leg showed recovery of the nerve function by interfacing with cYarn. Furthermore, the sciatic nerve functional index (SFI) at 16 weeks showed improvement in gait function. A 2% CNT density tended to be the most effective for nerve regeneration as measured by both histological axonal regeneration and motor function. We confirmed that CNT yarn promotes peripheral nerve regeneration by using it as a scaffold for repairing nerve defects. Our results support the future clinical application of CNTs for bridging nerve defects as an off-the-shelf material. |
format | Online Article Text |
id | pubmed-8486759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84867592021-10-04 Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect Kunisaki, Atsushi Kodama, Akira Ishikawa, Masakazu Ueda, Takahiro Lima, Marcio D. Kondo, Takeshi Adachi, Nobuo Sci Rep Article Carbon nanotubes (CNTs) are cylindrical nanostructures and have unique properties, including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn) as a possible substrate promoting peripheral nerve regeneration with these properties. We bridged a 15 mm rat sciatic nerve defect with five different densities of cYarn. Eight weeks after the surgery, the regenerated axons crossing the CNTs, electromyographical findings, and muscle weight ratio of the lower leg showed recovery of the nerve function by interfacing with cYarn. Furthermore, the sciatic nerve functional index (SFI) at 16 weeks showed improvement in gait function. A 2% CNT density tended to be the most effective for nerve regeneration as measured by both histological axonal regeneration and motor function. We confirmed that CNT yarn promotes peripheral nerve regeneration by using it as a scaffold for repairing nerve defects. Our results support the future clinical application of CNTs for bridging nerve defects as an off-the-shelf material. Nature Publishing Group UK 2021-10-01 /pmc/articles/PMC8486759/ /pubmed/34599218 http://dx.doi.org/10.1038/s41598-021-98603-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kunisaki, Atsushi Kodama, Akira Ishikawa, Masakazu Ueda, Takahiro Lima, Marcio D. Kondo, Takeshi Adachi, Nobuo Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect |
title | Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect |
title_full | Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect |
title_fullStr | Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect |
title_full_unstemmed | Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect |
title_short | Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect |
title_sort | carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486759/ https://www.ncbi.nlm.nih.gov/pubmed/34599218 http://dx.doi.org/10.1038/s41598-021-98603-7 |
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