In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets

MicroRNAs are small noncoding RNAs that have important roles in the lactation process and milk biosynthesis. Some polymorphisms have been studied in various livestock species from the perspective of pathology or production traits. To target variants that could be the causal variants of dairy traits,...

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Autores principales: Bourdon, Céline, Boussaha, Mekki, Bardou, Philippe, Sanchez, Marie-Pierre, Le Guillou, Sandrine, Tribout, Thierry, Larroque, Hélène, Boichard, Didier, Rupp, Rachel, Le Provost, Fabienne, Tosser-Klopp, Gwenola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486775/
https://www.ncbi.nlm.nih.gov/pubmed/34599210
http://dx.doi.org/10.1038/s41598-021-98639-9
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author Bourdon, Céline
Boussaha, Mekki
Bardou, Philippe
Sanchez, Marie-Pierre
Le Guillou, Sandrine
Tribout, Thierry
Larroque, Hélène
Boichard, Didier
Rupp, Rachel
Le Provost, Fabienne
Tosser-Klopp, Gwenola
author_facet Bourdon, Céline
Boussaha, Mekki
Bardou, Philippe
Sanchez, Marie-Pierre
Le Guillou, Sandrine
Tribout, Thierry
Larroque, Hélène
Boichard, Didier
Rupp, Rachel
Le Provost, Fabienne
Tosser-Klopp, Gwenola
author_sort Bourdon, Céline
collection PubMed
description MicroRNAs are small noncoding RNAs that have important roles in the lactation process and milk biosynthesis. Some polymorphisms have been studied in various livestock species from the perspective of pathology or production traits. To target variants that could be the causal variants of dairy traits, genetic variants of microRNAs expressed in the mammary gland or present in milk and localized in dairy quantitative trait loci (QTLs) were investigated in bovine, caprine, and ovine species. In this study, a total of 59,124 (out of 28 millions), 13,427 (out of 87 millions), and 4761 (out of 38 millions) genetic variants in microRNAs expressed in the mammary gland or present in milk were identified in bovine, caprine, and ovine species, respectively. A total of 4679 of these detected bovine genetic variants are located in dairy QTLs. In caprine species, 127 genetic variants are localized in dairy QTLs. In ovine species, no genetic variant was identified in dairy QTLs. This study leads to the detection of microRNA genetic variants of interest in the context of dairy production, taking advantage of whole genome data to identify microRNA genetic variants expressed in the mammary gland and localized in dairy QTLs.
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spelling pubmed-84867752021-10-04 In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets Bourdon, Céline Boussaha, Mekki Bardou, Philippe Sanchez, Marie-Pierre Le Guillou, Sandrine Tribout, Thierry Larroque, Hélène Boichard, Didier Rupp, Rachel Le Provost, Fabienne Tosser-Klopp, Gwenola Sci Rep Article MicroRNAs are small noncoding RNAs that have important roles in the lactation process and milk biosynthesis. Some polymorphisms have been studied in various livestock species from the perspective of pathology or production traits. To target variants that could be the causal variants of dairy traits, genetic variants of microRNAs expressed in the mammary gland or present in milk and localized in dairy quantitative trait loci (QTLs) were investigated in bovine, caprine, and ovine species. In this study, a total of 59,124 (out of 28 millions), 13,427 (out of 87 millions), and 4761 (out of 38 millions) genetic variants in microRNAs expressed in the mammary gland or present in milk were identified in bovine, caprine, and ovine species, respectively. A total of 4679 of these detected bovine genetic variants are located in dairy QTLs. In caprine species, 127 genetic variants are localized in dairy QTLs. In ovine species, no genetic variant was identified in dairy QTLs. This study leads to the detection of microRNA genetic variants of interest in the context of dairy production, taking advantage of whole genome data to identify microRNA genetic variants expressed in the mammary gland and localized in dairy QTLs. Nature Publishing Group UK 2021-10-01 /pmc/articles/PMC8486775/ /pubmed/34599210 http://dx.doi.org/10.1038/s41598-021-98639-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bourdon, Céline
Boussaha, Mekki
Bardou, Philippe
Sanchez, Marie-Pierre
Le Guillou, Sandrine
Tribout, Thierry
Larroque, Hélène
Boichard, Didier
Rupp, Rachel
Le Provost, Fabienne
Tosser-Klopp, Gwenola
In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_full In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_fullStr In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_full_unstemmed In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_short In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_sort in silico identification of variations in micrornas with a potential impact on dairy traits using whole ruminant genome snp datasets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486775/
https://www.ncbi.nlm.nih.gov/pubmed/34599210
http://dx.doi.org/10.1038/s41598-021-98639-9
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