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Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis

The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS1 leads to de novo synthesis of arginine, an important amin...

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Detalles Bibliográficos
Autores principales:	van der Meer, Jonathan H. M., de Boer, Ruben J., Meijer, Bartolomeus J., Smit, Wouter L., Vermeulen, Jacqueline L. M., Meisner, Sander, van Roest, Manon, Koelink, Pim J., Dekker, Evelien, Hakvoort, Theodorus B. M., Koster, Jan, Hawinkels, Lukas J. A. C., Heijmans, Jarom, Struijs, Eduard A., Boermeester, Marja A., van den Brink, Gijs R., Muncan, Vanesa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486827/ https://www.ncbi.nlm.nih.gov/pubmed/34599156 http://dx.doi.org/10.1038/s41419-021-04173-x

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