SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition

Geminin and its binding partner Cdt1 are essential for the regulation of DNA replication. Here we show that the CULLIN3 E3 ubiquitin ligase adaptor protein SPOP binds Geminin at endogenous level and regulates DNA replication. SPOP promotes K27-linked non-degradative poly-ubiquitination of Geminin at...

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Detalles Bibliográficos
Autores principales: Ma, Jian, Shi, Qing, Cui, Gaofeng, Sheng, Haoyue, Botuyan, Maria Victoria, Zhou, Yingke, Yan, Yuqian, He, Yundong, Wang, Liguo, Wang, Yuzhuo, Mer, Georges, Ye, Dingwei, Wang, Chenji, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486843/
https://www.ncbi.nlm.nih.gov/pubmed/34599168
http://dx.doi.org/10.1038/s41467-021-26049-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486843/
https://www.ncbi.nlm.nih.gov/pubmed/34599168
http://dx.doi.org/10.1038/s41467-021-26049-6

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