Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Germline specification in mammals occurs through an inductive process whereby competent cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The intrinsic factors that endow epiblast cells with the competence to respond to germline inductive signals remain unknown....

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Detalles Bibliográficos
Autores principales: Bleckwehl, Tore, Crispatzu, Giuliano, Schaaf, Kaitlin, Respuela, Patricia, Bartusel, Michaela, Benson, Laura, Clark, Stephen J., Dorighi, Kristel M., Barral, Antonio, Laugsch, Magdalena, van IJcken, Wilfred F. J., Manzanares, Miguel, Wysocka, Joanna, Reik, Wolf, Rada-Iglesias, Álvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486853/
https://www.ncbi.nlm.nih.gov/pubmed/34599190
http://dx.doi.org/10.1038/s41467-021-26065-6

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