Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain elusive. Here, we use a virus-like particle trapping technology to identify ISG15-binding proteins and discover Ring...

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Detalles Bibliográficos
Autores principales: Thery, Fabien, Martina, Lia, Asselman, Caroline, Zhang, Yifeng, Vessely, Madeleine, Repo, Heidi, Sedeyn, Koen, Moschonas, George D., Bredow, Clara, Teo, Qi Wen, Zhang, Jingshu, Leandro, Kevin, Eggermont, Denzel, De Sutter, Delphine, Boucher, Katie, Hochepied, Tino, Festjens, Nele, Callewaert, Nico, Saelens, Xavier, Dermaut, Bart, Knobeloch, Klaus-Peter, Beling, Antje, Sanyal, Sumana, Radoshevich, Lilliana, Eyckerman, Sven, Impens, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486878/
https://www.ncbi.nlm.nih.gov/pubmed/34599178
http://dx.doi.org/10.1038/s41467-021-26061-w

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