Hepatic Sensing Loop Regulates PCSK9 Secretion in Response to Inhibitory Antibodies

BACKGROUND: Monoclonal antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9i) lower LDL-C by up to 60% and increase plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels by 10-fold. OBJECTIVES: The authors studied the reasons behind the robust increase in plasma PCSK...

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Detalles Bibliográficos
Autores principales: Oleaga, Carlota, Shapiro, Michael D., Hay, Joshua, Mueller, Paul A., Miles, Joshua, Huang, Cecilia, Friz, Emily, Tavori, Hagai, Toth, Peter P., Wójcik, Cezary, Warden, Bruce A., Purnell, Jonathan Q., Duell, P. Barton, Pamir, Nathalie, Fazio, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486917/
https://www.ncbi.nlm.nih.gov/pubmed/34593126
http://dx.doi.org/10.1016/j.jacc.2021.07.056

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