Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper Accumulation

BACKGROUND & AIMS: The pathogenesis of Wilson disease (WD) involves hepatic and brain copper accumulation resulting from pathogenic variants affecting the ATP7B gene and downstream epigenetic and metabolic mechanisms. Prior methylome investigations in human WD liver and blood and in the Jackson...

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Detalles Bibliográficos
Autores principales: Sarode, Gaurav V., Neier, Kari, Shibata, Noreene M., Shen, Yuanjun, Goncharov, Dmitry A., Goncharova, Elena A., Mazi, Tagreed A., Joshi, Nikhil, Settles, Matthew L., LaSalle, Janine M., Medici, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487080/
https://www.ncbi.nlm.nih.gov/pubmed/34098115
http://dx.doi.org/10.1016/j.jcmgh.2021.05.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487080/
https://www.ncbi.nlm.nih.gov/pubmed/34098115
http://dx.doi.org/10.1016/j.jcmgh.2021.05.020

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