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Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia

BACKGROUND: Viral-based immunotherapy can overcome resistance to immune checkpoint blockade (ICB) and fill the unmet needs of many patients with cancer. Oncolytic viruses (OVs) are defined as engineered or naturally occurring viruses that selectively replicate in and kill cancer cells. OVs also indu...

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Detalles Bibliográficos
Autores principales: Wang, Weiyi, Liu, Shuaitong, Dai, Peihong, Yang, Ning, Wang, Yi, Giese, Rachel A, Merghoub, Taha, Wolchok, Jedd, Deng, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487208/
https://www.ncbi.nlm.nih.gov/pubmed/34593618
http://dx.doi.org/10.1136/jitc-2021-002569