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Multichannel esophageal signals to monitor respiratory rate in preterm infants

BACKGROUND: Apnea of prematurity cannot be reliably measured with current monitoring techniques. Instead, indirect parameters such as oxygen desaturation or bradycardia are captured. We propose a Kalman filter-based detection of respiration activity and hence apnea using multichannel esophageal sign...

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Autores principales: Bürgin, Corine, Simmen, Patrizia, Gupta, Nishant, Suter, Lilian, Kreuzer, Samuel, Haeberlin, Andreas, Schulzke, Sven M., Trachsel, Daniel, Niederhauser, Thomas, Jost, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487228/
https://www.ncbi.nlm.nih.gov/pubmed/34601494
http://dx.doi.org/10.1038/s41390-021-01748-4
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author Bürgin, Corine
Simmen, Patrizia
Gupta, Nishant
Suter, Lilian
Kreuzer, Samuel
Haeberlin, Andreas
Schulzke, Sven M.
Trachsel, Daniel
Niederhauser, Thomas
Jost, Kerstin
author_facet Bürgin, Corine
Simmen, Patrizia
Gupta, Nishant
Suter, Lilian
Kreuzer, Samuel
Haeberlin, Andreas
Schulzke, Sven M.
Trachsel, Daniel
Niederhauser, Thomas
Jost, Kerstin
author_sort Bürgin, Corine
collection PubMed
description BACKGROUND: Apnea of prematurity cannot be reliably measured with current monitoring techniques. Instead, indirect parameters such as oxygen desaturation or bradycardia are captured. We propose a Kalman filter-based detection of respiration activity and hence apnea using multichannel esophageal signals in neonatal intensive care unit patients. METHODS: We performed a single-center observational study with moderately preterm infants. Commercially available nasogastric feeding tubes containing multiple electrodes were used to capture signals with customized software. Multichannel esophageal raw signals were manually annotated, processed using extended Kalman filter, and compared with standard monitoring data including chest impedance to measure respiration activity. RESULTS: Out of a total of 405.4 h captured signals in 13 infants, 100 episodes of drop in oxygen saturation or heart rate were examined. Median (interquartile range) difference in respiratory rate was 0.04 (−2.45 to 1.48)/min between esophageal measurements annotated manually and with Kalman filter and −3.51 (−7.05 to −1.33)/min when compared to standard monitoring, suggesting an underestimation of respiratory rate when using the latter. CONCLUSIONS: Kalman filter-based estimation of respiratory activity using multichannel esophageal signals is safe and feasible and results in respiratory rate closer to visual annotation than that derived from chest impedance of standard monitoring.
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spelling pubmed-84872282021-10-04 Multichannel esophageal signals to monitor respiratory rate in preterm infants Bürgin, Corine Simmen, Patrizia Gupta, Nishant Suter, Lilian Kreuzer, Samuel Haeberlin, Andreas Schulzke, Sven M. Trachsel, Daniel Niederhauser, Thomas Jost, Kerstin Pediatr Res Clinical Research Article BACKGROUND: Apnea of prematurity cannot be reliably measured with current monitoring techniques. Instead, indirect parameters such as oxygen desaturation or bradycardia are captured. We propose a Kalman filter-based detection of respiration activity and hence apnea using multichannel esophageal signals in neonatal intensive care unit patients. METHODS: We performed a single-center observational study with moderately preterm infants. Commercially available nasogastric feeding tubes containing multiple electrodes were used to capture signals with customized software. Multichannel esophageal raw signals were manually annotated, processed using extended Kalman filter, and compared with standard monitoring data including chest impedance to measure respiration activity. RESULTS: Out of a total of 405.4 h captured signals in 13 infants, 100 episodes of drop in oxygen saturation or heart rate were examined. Median (interquartile range) difference in respiratory rate was 0.04 (−2.45 to 1.48)/min between esophageal measurements annotated manually and with Kalman filter and −3.51 (−7.05 to −1.33)/min when compared to standard monitoring, suggesting an underestimation of respiratory rate when using the latter. CONCLUSIONS: Kalman filter-based estimation of respiratory activity using multichannel esophageal signals is safe and feasible and results in respiratory rate closer to visual annotation than that derived from chest impedance of standard monitoring. Nature Publishing Group US 2021-10-02 2022 /pmc/articles/PMC8487228/ /pubmed/34601494 http://dx.doi.org/10.1038/s41390-021-01748-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Research Article
Bürgin, Corine
Simmen, Patrizia
Gupta, Nishant
Suter, Lilian
Kreuzer, Samuel
Haeberlin, Andreas
Schulzke, Sven M.
Trachsel, Daniel
Niederhauser, Thomas
Jost, Kerstin
Multichannel esophageal signals to monitor respiratory rate in preterm infants
title Multichannel esophageal signals to monitor respiratory rate in preterm infants
title_full Multichannel esophageal signals to monitor respiratory rate in preterm infants
title_fullStr Multichannel esophageal signals to monitor respiratory rate in preterm infants
title_full_unstemmed Multichannel esophageal signals to monitor respiratory rate in preterm infants
title_short Multichannel esophageal signals to monitor respiratory rate in preterm infants
title_sort multichannel esophageal signals to monitor respiratory rate in preterm infants
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487228/
https://www.ncbi.nlm.nih.gov/pubmed/34601494
http://dx.doi.org/10.1038/s41390-021-01748-4
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