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6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro

The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attractive drug target as it is essential for viral polyprotein...

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Detalles Bibliográficos
Autores principales:	Swaim, Caleb D., Dwivedi, Varun, Perng, Yi-Chieh, Zhao, Xu, Canadeo, Larissa A., Harastani, Houda H., Darling, Tamarand L., Boon, Adrianus C.M., Lenschow, Deborah J., Kulkarni, Viraj, Huibregtse, Jon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487320/ https://www.ncbi.nlm.nih.gov/pubmed/34632326 http://dx.doi.org/10.1016/j.isci.2021.103213

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