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Current trends in diagnosis and treatment strategies of COVID-19 infection
Coronaviruses are terrifically precise and adapted towards specialized respiratory epithelial cells, observed in organ culture and human volunteers both. This virus is found to possess an unpredictable anti-viral T-cell response which in turn results in T-cell activation and finally apoptosis, leadi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487330/ https://www.ncbi.nlm.nih.gov/pubmed/34601675 http://dx.doi.org/10.1007/s11356-021-16715-z |
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author | Tiwari, Varsha Kumar, Manish Tiwari, Abhishek Sahoo, Biswa Mohan Singh, Sunil Kumar, Suresh Saharan, Renu |
author_facet | Tiwari, Varsha Kumar, Manish Tiwari, Abhishek Sahoo, Biswa Mohan Singh, Sunil Kumar, Suresh Saharan, Renu |
author_sort | Tiwari, Varsha |
collection | PubMed |
description | Coronaviruses are terrifically precise and adapted towards specialized respiratory epithelial cells, observed in organ culture and human volunteers both. This virus is found to possess an unpredictable anti-viral T-cell response which in turn results in T-cell activation and finally apoptosis, leading to cytokine storm and collapse of the whole immune system. The present review provides comprehensive information regarding SARS-CoV-2 infection, mutant strains, and the impact of SARS-COV-2 on vital organs, the pathophysiology of the disease, diagnostic tests available, and possible treatments. It also includes all the vaccines developed so far throughout the world to control this pandemic. Until now, 18 vaccines have been approved by the WHO and further 22 vaccines are in the third trial. This study also provides up-to-date information regarding the drugs repurposed in clinical trials and the recent status of allopathic drugs along with its result. Although vaccines are available, specific treatment is not available for the disease. Furthermore, the effect of vaccines on new variants is a new area of research at this time. Therefore, a preventive attitude is the best approach to fight against this virus. |
format | Online Article Text |
id | pubmed-8487330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-84873302021-10-04 Current trends in diagnosis and treatment strategies of COVID-19 infection Tiwari, Varsha Kumar, Manish Tiwari, Abhishek Sahoo, Biswa Mohan Singh, Sunil Kumar, Suresh Saharan, Renu Environ Sci Pollut Res Int Review Article Coronaviruses are terrifically precise and adapted towards specialized respiratory epithelial cells, observed in organ culture and human volunteers both. This virus is found to possess an unpredictable anti-viral T-cell response which in turn results in T-cell activation and finally apoptosis, leading to cytokine storm and collapse of the whole immune system. The present review provides comprehensive information regarding SARS-CoV-2 infection, mutant strains, and the impact of SARS-COV-2 on vital organs, the pathophysiology of the disease, diagnostic tests available, and possible treatments. It also includes all the vaccines developed so far throughout the world to control this pandemic. Until now, 18 vaccines have been approved by the WHO and further 22 vaccines are in the third trial. This study also provides up-to-date information regarding the drugs repurposed in clinical trials and the recent status of allopathic drugs along with its result. Although vaccines are available, specific treatment is not available for the disease. Furthermore, the effect of vaccines on new variants is a new area of research at this time. Therefore, a preventive attitude is the best approach to fight against this virus. Springer Berlin Heidelberg 2021-10-02 2021 /pmc/articles/PMC8487330/ /pubmed/34601675 http://dx.doi.org/10.1007/s11356-021-16715-z Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Tiwari, Varsha Kumar, Manish Tiwari, Abhishek Sahoo, Biswa Mohan Singh, Sunil Kumar, Suresh Saharan, Renu Current trends in diagnosis and treatment strategies of COVID-19 infection |
title | Current trends in diagnosis and treatment strategies of COVID-19 infection |
title_full | Current trends in diagnosis and treatment strategies of COVID-19 infection |
title_fullStr | Current trends in diagnosis and treatment strategies of COVID-19 infection |
title_full_unstemmed | Current trends in diagnosis and treatment strategies of COVID-19 infection |
title_short | Current trends in diagnosis and treatment strategies of COVID-19 infection |
title_sort | current trends in diagnosis and treatment strategies of covid-19 infection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487330/ https://www.ncbi.nlm.nih.gov/pubmed/34601675 http://dx.doi.org/10.1007/s11356-021-16715-z |
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