Decrease in Skin Prion-Seeding Activity of Prion-Infected Mice Treated with a Compound Against Human and Animal Prions: a First Possible Biomarker for Prion Therapeutics

Previous studies have revealed that the infectious scrapie isoform of prion protein (PrP(Sc)) harbored in the skin tissue of patients or animals with prion diseases can be amplified and detected through the serial protein misfolding cyclic amplification (sPMCA) or real-time quaking-induced conversio...

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Detalles Bibliográficos
Autores principales: Ding, Mingxuan, Teruya, Kenta, Zhang, Weiguanliu, Lee, Hae Weon, Yuan, Jue, Oguma, Ayumi, Foutz, Aaron, Camacho, Manuel V., Mitchell, Marcus, Greenlee, Justin J., Kong, Qingzhong, Doh-ura, Katsumi, Cui, Li, Zou, Wen-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487418/
https://www.ncbi.nlm.nih.gov/pubmed/33983547
http://dx.doi.org/10.1007/s12035-021-02418-6

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