Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway

Prolonged cellular hypoxia leads to energetic failure and death. However, sublethal hypoxia can trigger an adaptive response called hypoxic preconditioning. While prolyl-hydroxylase (PHD) enzymes and hypoxia-inducible factors (HIFs) have been identified as key elements of oxygen-sensing machinery, t...

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Detalles Bibliográficos
Autores principales: Torosyan, Rafael, Huang, Shengping, Bommi, Prashant V., Tiwari, Ratnakar, An, Si Young, Schonfeld, Michael, Rajendran, Ganeshkumar, Kavanaugh, Matthew A., Gibbs, Benjamin, Truax, Agnieszka D., Bohney, Samuel, Calcutt, M. Wade, Kerr, Evan W., Leonardi, Roberta, Gao, Peng, Chandel, Navdeep S., Kapitsinou, Pinelopi P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487442/
https://www.ncbi.nlm.nih.gov/pubmed/34407414
http://dx.doi.org/10.1016/j.celrep.2021.109547

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