Genome mining of novel rubiginones from Streptomyces sp. CB02414 and characterization of the post-PKS modification steps in rubiginone biosynthesis

BACKGROUND: Rubiginones belong to the angucycline family of aromatic polyketides, and they have been shown to potentiate the vincristine (VCR)-induced cytotoxicity against VCR-resistant cancer cell lines. However, the biosynthetic gene clusters (BGCs) and biosynthetic pathways for rubiginones have n...

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Detalles Bibliográficos
Autores principales: Zhang, Jingyan, Sun, Ying, Wang, Yeji, Chen, Xin, Xue, Lu, Zhang, Jingjing, Zhu, Xiangcheng, Duan, Yanwen, Yan, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487521/
https://www.ncbi.nlm.nih.gov/pubmed/34600534
http://dx.doi.org/10.1186/s12934-021-01681-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487521/
https://www.ncbi.nlm.nih.gov/pubmed/34600534
http://dx.doi.org/10.1186/s12934-021-01681-5

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