Cargando…

Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes

BACKGROUND: Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid arthritis synovial tissue. Shikonin has anti-inflammatory and immunomodulatory ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Lianhua, Luan, Huijie, He, Juan, Zhang, Miaomiao, Qin, Qingxia, Hu, Yiping, Cai, Yueming, Sun, Desheng, Shi, Yu, Wang, Qingwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487562/ https://www.ncbi.nlm.nih.gov/pubmed/34600581 http://dx.doi.org/10.1186/s13020-021-00510-6

Ejemplares similares

Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3‐mediated N6‐methyladenosine modification of ICAM2 mRNA in fibroblast‐like synoviocytes
por: Chen, Jian, et al.
Publicado: (2022)

Joint Location–Specific JAK‐STAT Signaling in Rheumatoid Arthritis Fibroblast‐like Synoviocytes
por: Hammaker, Deepa, et al.
Publicado: (2019)

Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling
por: Wu, Jia-Ying, et al.
Publicado: (2022)

Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis
por: Wang, Heng, et al.
Publicado: (2012)

C-Reactive Protein Promotes the Activation of Fibroblast-Like Synoviocytes From Patients With Rheumatoid Arthritis
por: Fang, Zhengyu, et al.
Publicado: (2020)

CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes
por: Migita, Kiyoshi, et al.
Publicado: (2011)

Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit
por: Yang, Xilan, et al.
Publicado: (2020)

The molecular basis of JAK/STAT inhibition by SOCS1
por: Liau, Nicholas P. D., et al.
Publicado: (2018)

CS12192, a Novel JAK3/JAK1/TBK1 Inhibitor, Synergistically Enhances the Anti-Inflammation Effect of Methotrexate in a Rat Model of Rheumatoid Arthritis
por: Fang, Zhengyu, et al.
Publicado: (2022)

Role and mechanism of fibroblast-activated protein-α expression on the surface of fibroblast-like synoviocytes in rheumatoid arthritis
por: Wang, Zihan, et al.
Publicado: (2023)

High-Throughput Study of the Effects of Celastrol on Activated Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis
por: Fang, Zhengyu, et al.
Publicado: (2017)

Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes
por: Choe, Jung-Yoon, et al.
Publicado: (2013)

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity
por: Wunderlich, Claudia M., et al.
Publicado: (2013)

KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway
por: Zhang, Xin, et al.
Publicado: (2021)

Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis
por: Bustamante, Marta F., et al.
Publicado: (2017)

Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes
por: Lin, Jin, et al.
Publicado: (2019)

Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
por: He, Shou-Di, et al.
Publicado: (2020)

SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis
por: Pandey, Rahul, et al.
Publicado: (2023)

Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway
por: Qin, Kaili, et al.
Publicado: (2018)

PTEN Methylation Promotes Inflammation and Activation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
por: Li, Xiao-Feng, et al.
Publicado: (2021)

Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes
por: Bauer, Stefan, et al.
Publicado: (2006)

Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis
por: Kaneko, Kayoko, et al.
Publicado: (2011)

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
por: Ai, Rizi, et al.
Publicado: (2018)

EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling
por: Liu, Ze-Kun, et al.
Publicado: (2021)

Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway
por: Yang, Yongsheng, et al.
Publicado: (2017)

The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology
por: Sims, Natalie A.
Publicado: (2020)

Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis
por: Kopalli, Spandana Rajendra, et al.
Publicado: (2022)

SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway
por: Chen, Mo, et al.
Publicado: (2020)

miR-150-Based RNA Interference Attenuates Tubulointerstitial Fibrosis through the SOCS1/JAK/STAT Pathway In Vivo and In Vitro
por: Luan, Junjun, et al.
Publicado: (2020)

Metabolomic Elucidation of the Effects of Curcumin on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
por: Ahn, Joong Kyong, et al.
Publicado: (2015)

Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes
por: Torres, Alyssa, et al.
Publicado: (2022)

Apoptosis in Rheumatoid Synoviocytes
por: Nishioka, Kusuki
Publicado: (2000)

miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling
por: Collins, Aideen S., et al.
Publicado: (2013)

Involvement of JAK-STAT-SOCS3 Pathway in the Regression of Mice X-Zone of Adrenal Cortex
por: Auricino, Thais Barabba, et al.
Publicado: (2021)

The mechanism of oxymatrine on atopic dermatitis in mice based on SOCS1/JAK-STAT3 pathway
por: Han, Xianwei, et al.
Publicado: (2023)

Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
por: Li, Jiahui, et al.
Publicado: (2021)

Aspirin promotes apoptosis and inhibits proliferation by blocking G(0)/G(1) into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway
por: Zhang, Xiaoqi, et al.
Publicado: (2018)

HOXD10 silencing suppresses human fibroblast-like synoviocyte migration in rheumatoid arthritis via downregulation of the p38/JNK pathway
por: Luan, Luan, et al.
Publicado: (2018)

Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
por: Chen, Danna, et al.
Publicado: (2017)

SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review
por: Jiang, Ping, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0f4vat9hdgfivqles2sc86uiv8