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Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice
Mice are a widely used pre-clinical model system in large part due to their potential for genetic manipulation. The ability to manipulate gene expression in specific cells under temporal control is a powerful experimental tool. The liver is central to metabolic homeostasis and a site of many disease...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487635/ https://www.ncbi.nlm.nih.gov/pubmed/34435198 http://dx.doi.org/10.1242/bio.058678 |