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Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Lung cancer is the leading cause of cancer-related deaths in the USA and worldwide. Yet, about 95% of new drug candidates validated in preclinical phase eventually fail in clinical trials. Such a high attrition rate is attributed mostly to the inability of conventional two-dimensionally (2D) culture...

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Detalles Bibliográficos
Autores principales:	Kaczmarczyk, Jan A., Roberts, Rhonda R., Luke, Brian T., Chan, King C., Van Wagoner, Carly M., Felder, Robin A., Saul, Richard G., Simona, Colantonio, Blonder, Josip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487723/ https://www.ncbi.nlm.nih.gov/pubmed/34611477 http://dx.doi.org/10.18632/oncotarget.28072

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