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Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells

Colorectal cancer (CRC) caused over 900,000 deaths worldwide in 2020. A majority of late-stage CRC patients are treated with 5-fluorouracil (5-FU) combined with either irinotecan (CPT-11), oxaliplatin, or both. Despite their widespread use, the mechanisms of efficacy and toxicity of these drugs rema...

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Detalles Bibliográficos
Autores principales:	Carlsen, Lindsey, Schorl, Christoph, Huntington, Kelsey, Hernandez-Borrero, Liz, Jhaveri, Aakash, Zhang, Shengliang, Zhou, Lanlan, El-Deiry, Wafik S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487728/ https://www.ncbi.nlm.nih.gov/pubmed/34611476 http://dx.doi.org/10.18632/oncotarget.28075

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