Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination

The ChAdOx1 nCoV-19 adenoviral vector vaccine to prevent contracting Covid-19 caused by infection with SARS-CoV-2 has been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) primarily leading to venous thromboses. Here, we report two cases of major arterial occlusions after Ch...

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Autores principales: Goereci, Yasemin, Kleineberg, Nina N., Madlener, Marie, Neuschmelting, Hannah, Fink, Gereon R., Warnke, Clemens, Stetefeld, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487755/
https://www.ncbi.nlm.nih.gov/pubmed/34602097
http://dx.doi.org/10.1186/s42466-021-00151-y
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author Goereci, Yasemin
Kleineberg, Nina N.
Madlener, Marie
Neuschmelting, Hannah
Fink, Gereon R.
Warnke, Clemens
Stetefeld, Henning
author_facet Goereci, Yasemin
Kleineberg, Nina N.
Madlener, Marie
Neuschmelting, Hannah
Fink, Gereon R.
Warnke, Clemens
Stetefeld, Henning
author_sort Goereci, Yasemin
collection PubMed
description The ChAdOx1 nCoV-19 adenoviral vector vaccine to prevent contracting Covid-19 caused by infection with SARS-CoV-2 has been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) primarily leading to venous thromboses. Here, we report two cases of major arterial occlusions after ChAdOx1 nCov-19 vaccination, comprising a 42-year-old woman with thrombotic occlusion of the left carotid artery, and a 62-year-old man with occlusion of distal aorta and iliac arteries. Both were successfully treated with intravenous immunoglobulins and non-heparin anticoagulant agents leading to a beneficial short-term outcome of 6 weeks in case 1 and four months in case 2.
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spelling pubmed-84877552021-10-04 Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination Goereci, Yasemin Kleineberg, Nina N. Madlener, Marie Neuschmelting, Hannah Fink, Gereon R. Warnke, Clemens Stetefeld, Henning Neurol Res Pract Letter to the Editor The ChAdOx1 nCoV-19 adenoviral vector vaccine to prevent contracting Covid-19 caused by infection with SARS-CoV-2 has been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) primarily leading to venous thromboses. Here, we report two cases of major arterial occlusions after ChAdOx1 nCov-19 vaccination, comprising a 42-year-old woman with thrombotic occlusion of the left carotid artery, and a 62-year-old man with occlusion of distal aorta and iliac arteries. Both were successfully treated with intravenous immunoglobulins and non-heparin anticoagulant agents leading to a beneficial short-term outcome of 6 weeks in case 1 and four months in case 2. BioMed Central 2021-10-04 /pmc/articles/PMC8487755/ /pubmed/34602097 http://dx.doi.org/10.1186/s42466-021-00151-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Letter to the Editor
Goereci, Yasemin
Kleineberg, Nina N.
Madlener, Marie
Neuschmelting, Hannah
Fink, Gereon R.
Warnke, Clemens
Stetefeld, Henning
Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination
title Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination
title_full Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination
title_fullStr Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination
title_full_unstemmed Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination
title_short Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination
title_sort successful treatment of thromboses of major arteries after chadox1 ncov-19 vaccination
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487755/
https://www.ncbi.nlm.nih.gov/pubmed/34602097
http://dx.doi.org/10.1186/s42466-021-00151-y
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