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Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices

In this work, the applicability of direct analysis in real time coupled to accurate mass spectrometry (DART-MS) to the quantitative determination of triclosan (TCS) in samples with increasing complexity, from personal care products to extracts from sewage, is investigated. In the first term, DART-MS...

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Autores principales: Cobo-Golpe, M., García-Martín, J., Ramil, M., Cela, R., Rodríguez, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487875/
https://www.ncbi.nlm.nih.gov/pubmed/34378070
http://dx.doi.org/10.1007/s00216-021-03591-2
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author Cobo-Golpe, M.
García-Martín, J.
Ramil, M.
Cela, R.
Rodríguez, I.
author_facet Cobo-Golpe, M.
García-Martín, J.
Ramil, M.
Cela, R.
Rodríguez, I.
author_sort Cobo-Golpe, M.
collection PubMed
description In this work, the applicability of direct analysis in real time coupled to accurate mass spectrometry (DART-MS) to the quantitative determination of triclosan (TCS) in samples with increasing complexity, from personal care products to extracts from sewage, is investigated. In the first term, DART-MS spectra of TCS as free phenol and as derivatized species are characterized; thereafter, the effects of several instrumental variables in the detectability of TCS (i.e., temperature, solvent, and compound holder) are discussed. Under final selected conditions, TCS was determined from its [M-H](−) ions, without need of derivatization, attaining an instrumental limit of quantification of 5 ng mL(−1), with a linear response range up to 1000 ng mL(−1). Complex matrices, such as solid-phase extracts obtained from environmental water samples, moderately inhibited the ionization efficiency of TCS, with signal attenuation percentages in the range of 6 to 57%, depending on the sample type and on the concentration factor provided by the SPE procedure. The accuracy of results obtained by DART-MS was evaluated using liquid chromatography (LC) with MS detection; in both cases, a time-of-flight (TOF) MS instrument was employed for the selective determination of the [M−H](−) ions of TCS (m/z values 286.9439 and 288.9410) using a mass window of 20 ppm. DART-MS did not only provide enough sensitivity to detect the presence of TCS in environmental samples (raw and treated wastewater as well as freeze-dried sludge), but also measured concentrations matched those determined by LC-ESI-TOF-MS, with only slightly higher standard deviations. During analysis of personal care products, containing much higher concentrations of TCS in a less complex matrix, both techniques were equivalent in terms of accuracy and precision. [Figure: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00216-021-03591-2.
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spelling pubmed-84878752021-10-14 Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices Cobo-Golpe, M. García-Martín, J. Ramil, M. Cela, R. Rodríguez, I. Anal Bioanal Chem Research Paper In this work, the applicability of direct analysis in real time coupled to accurate mass spectrometry (DART-MS) to the quantitative determination of triclosan (TCS) in samples with increasing complexity, from personal care products to extracts from sewage, is investigated. In the first term, DART-MS spectra of TCS as free phenol and as derivatized species are characterized; thereafter, the effects of several instrumental variables in the detectability of TCS (i.e., temperature, solvent, and compound holder) are discussed. Under final selected conditions, TCS was determined from its [M-H](−) ions, without need of derivatization, attaining an instrumental limit of quantification of 5 ng mL(−1), with a linear response range up to 1000 ng mL(−1). Complex matrices, such as solid-phase extracts obtained from environmental water samples, moderately inhibited the ionization efficiency of TCS, with signal attenuation percentages in the range of 6 to 57%, depending on the sample type and on the concentration factor provided by the SPE procedure. The accuracy of results obtained by DART-MS was evaluated using liquid chromatography (LC) with MS detection; in both cases, a time-of-flight (TOF) MS instrument was employed for the selective determination of the [M−H](−) ions of TCS (m/z values 286.9439 and 288.9410) using a mass window of 20 ppm. DART-MS did not only provide enough sensitivity to detect the presence of TCS in environmental samples (raw and treated wastewater as well as freeze-dried sludge), but also measured concentrations matched those determined by LC-ESI-TOF-MS, with only slightly higher standard deviations. During analysis of personal care products, containing much higher concentrations of TCS in a less complex matrix, both techniques were equivalent in terms of accuracy and precision. [Figure: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00216-021-03591-2. Springer Berlin Heidelberg 2021-08-10 2021 /pmc/articles/PMC8487875/ /pubmed/34378070 http://dx.doi.org/10.1007/s00216-021-03591-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Paper
Cobo-Golpe, M.
García-Martín, J.
Ramil, M.
Cela, R.
Rodríguez, I.
Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
title Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
title_full Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
title_fullStr Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
title_full_unstemmed Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
title_short Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
title_sort assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487875/
https://www.ncbi.nlm.nih.gov/pubmed/34378070
http://dx.doi.org/10.1007/s00216-021-03591-2
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