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High endothelial venules (HEVs) in immunity, inflammation and cancer
High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high levels of lymphocyte extravasation from the blood, HEVs play an essential role in lymphocyte recirculation and immune surveillan...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Netherlands
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487881/ https://www.ncbi.nlm.nih.gov/pubmed/33956259 http://dx.doi.org/10.1007/s10456-021-09792-8 |
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author | Blanchard, Lucas Girard, Jean-Philippe |
author_facet | Blanchard, Lucas Girard, Jean-Philippe |
author_sort | Blanchard, Lucas |
collection | PubMed |
description | High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high levels of lymphocyte extravasation from the blood, HEVs play an essential role in lymphocyte recirculation and immune surveillance for foreign invaders (bacterial and viral infections) and alterations in the body’s own cells (neoantigens in cancer). The HEV network expands during inflammation in immune-stimulated LNs and is profoundly remodeled in metastatic and tumor-draining LNs. HEV-like blood vessels expressing high levels of the HEV-specific sulfated MECA-79 antigens are induced in non-lymphoid tissues at sites of chronic inflammation in many human inflammatory and allergic diseases, including rheumatoid arthritis, Crohn’s disease, allergic rhinitis and asthma. Such vessels are believed to contribute to the amplification and maintenance of chronic inflammation. MECA-79(+) tumor-associated HEVs (TA-HEVs) are frequently found in human tumors in CD3(+) T cell-rich areas or CD20(+) B-cell rich tertiary lymphoid structures (TLSs). TA-HEVs have been proposed to play important roles in lymphocyte entry into tumors, a process essential for successful antitumor immunity and lymphocyte-mediated cancer immunotherapy with immune checkpoint inhibitors, vaccines or adoptive T cell therapy. In this review, we highlight the phenotype and function of HEVs in homeostatic, inflamed and tumor-draining lymph nodes, and those of HEV-like blood vessels in chronic inflammatory diseases. Furthermore, we discuss the role and regulation of TA-HEVs in human cancer and mouse tumor models. |
format | Online Article Text |
id | pubmed-8487881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-84878812021-10-14 High endothelial venules (HEVs) in immunity, inflammation and cancer Blanchard, Lucas Girard, Jean-Philippe Angiogenesis Review Paper High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high levels of lymphocyte extravasation from the blood, HEVs play an essential role in lymphocyte recirculation and immune surveillance for foreign invaders (bacterial and viral infections) and alterations in the body’s own cells (neoantigens in cancer). The HEV network expands during inflammation in immune-stimulated LNs and is profoundly remodeled in metastatic and tumor-draining LNs. HEV-like blood vessels expressing high levels of the HEV-specific sulfated MECA-79 antigens are induced in non-lymphoid tissues at sites of chronic inflammation in many human inflammatory and allergic diseases, including rheumatoid arthritis, Crohn’s disease, allergic rhinitis and asthma. Such vessels are believed to contribute to the amplification and maintenance of chronic inflammation. MECA-79(+) tumor-associated HEVs (TA-HEVs) are frequently found in human tumors in CD3(+) T cell-rich areas or CD20(+) B-cell rich tertiary lymphoid structures (TLSs). TA-HEVs have been proposed to play important roles in lymphocyte entry into tumors, a process essential for successful antitumor immunity and lymphocyte-mediated cancer immunotherapy with immune checkpoint inhibitors, vaccines or adoptive T cell therapy. In this review, we highlight the phenotype and function of HEVs in homeostatic, inflamed and tumor-draining lymph nodes, and those of HEV-like blood vessels in chronic inflammatory diseases. Furthermore, we discuss the role and regulation of TA-HEVs in human cancer and mouse tumor models. Springer Netherlands 2021-05-06 2021 /pmc/articles/PMC8487881/ /pubmed/33956259 http://dx.doi.org/10.1007/s10456-021-09792-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Paper Blanchard, Lucas Girard, Jean-Philippe High endothelial venules (HEVs) in immunity, inflammation and cancer |
title | High endothelial venules (HEVs) in immunity, inflammation and cancer |
title_full | High endothelial venules (HEVs) in immunity, inflammation and cancer |
title_fullStr | High endothelial venules (HEVs) in immunity, inflammation and cancer |
title_full_unstemmed | High endothelial venules (HEVs) in immunity, inflammation and cancer |
title_short | High endothelial venules (HEVs) in immunity, inflammation and cancer |
title_sort | high endothelial venules (hevs) in immunity, inflammation and cancer |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487881/ https://www.ncbi.nlm.nih.gov/pubmed/33956259 http://dx.doi.org/10.1007/s10456-021-09792-8 |
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