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ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model

OBJECTIVE: Activating transcription factor 4 (ATF4) is a transcriptional regulator of the unfolded protein response and integrated stress response (ISR) that promote the restoration of normal endoplasmic reticulum (ER) function. Previous reports demonstrated that dysregulation of the ISR led to deve...

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Detalles Bibliográficos
Autores principales:	Kitakaze, Keisuke, Oyadomari, Miho, Zhang, Jun, Hamada, Yoshimasa, Takenouchi, Yasuhiro, Tsuboi, Kazuhito, Inagaki, Mai, Tachikawa, Masanori, Fujitani, Yoshio, Okamoto, Yasuo, Oyadomari, Seiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487982/ https://www.ncbi.nlm.nih.gov/pubmed/34547510 http://dx.doi.org/10.1016/j.molmet.2021.101338

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