Cargando…

Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma

Epidemiological investigations have shown that patients with Parkinson’s disease (PD) have a lower probability of developing lung cancer. Subsequent research revealed that PD and lung cancer share specific genetic alterations. Therefore, the utilisation of PD biomarkers and therapeutic targets may i...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yanqi, Lu, Xiao, Zhang, Jiao, Liu, Quanxing, Zhou, Dong, Deng, Xufeng, Qiu, Yuan, Chen, Qian, Li, Manyuan, Yang, Guixue, Zheng, Hong, Dai, Jigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488091/
https://www.ncbi.nlm.nih.gov/pubmed/34616772
http://dx.doi.org/10.3389/fmolb.2021.735263
_version_ 1784578079356616704
author Li, Yanqi
Lu, Xiao
Zhang, Jiao
Liu, Quanxing
Zhou, Dong
Deng, Xufeng
Qiu, Yuan
Chen, Qian
Li, Manyuan
Yang, Guixue
Zheng, Hong
Dai, Jigang
author_facet Li, Yanqi
Lu, Xiao
Zhang, Jiao
Liu, Quanxing
Zhou, Dong
Deng, Xufeng
Qiu, Yuan
Chen, Qian
Li, Manyuan
Yang, Guixue
Zheng, Hong
Dai, Jigang
author_sort Li, Yanqi
collection PubMed
description Epidemiological investigations have shown that patients with Parkinson’s disease (PD) have a lower probability of developing lung cancer. Subsequent research revealed that PD and lung cancer share specific genetic alterations. Therefore, the utilisation of PD biomarkers and therapeutic targets may improve lung adenocarcinoma (LUAD) diagnosis and treatment. We aimed to identify a gene-based signature from 25 Parkinson family genes for LUAD prognosis and treatment choice. We analysed Parkinson family gene expression and protein levels in LUAD, utilising multiple databases. Least absolute shrinkage and selection operator (LASSO) regression was used to construct a prognostic model based on the TCGA-LUAD cohort. We validated the model in external GEO cohorts. Immune cell infiltration was compared between risk groups, and GEO data was used to explore the model’s predictive ability for LUAD treatment response. Nearly all Parkinson family genes exhibited significant differential expression between LUAD and normal tissues. LASSO regression confirmed that our seven Parkinson family gene-based signature had excellent prognostic performance for LUAD, as validated in three GEO cohorts. The high-risk group was clearly associated with low tumour immune cell infiltration, suggesting that immunotherapy may not be an optimal treatment choice. This is the first Parkinson family gene-based model for the prediction of LUAD prognosis and treatment outcome. The association of these genes with poor prognosis and low immune infiltration requires further investigation.
format Online
Article
Text
id pubmed-8488091
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84880912021-10-05 Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma Li, Yanqi Lu, Xiao Zhang, Jiao Liu, Quanxing Zhou, Dong Deng, Xufeng Qiu, Yuan Chen, Qian Li, Manyuan Yang, Guixue Zheng, Hong Dai, Jigang Front Mol Biosci Molecular Biosciences Epidemiological investigations have shown that patients with Parkinson’s disease (PD) have a lower probability of developing lung cancer. Subsequent research revealed that PD and lung cancer share specific genetic alterations. Therefore, the utilisation of PD biomarkers and therapeutic targets may improve lung adenocarcinoma (LUAD) diagnosis and treatment. We aimed to identify a gene-based signature from 25 Parkinson family genes for LUAD prognosis and treatment choice. We analysed Parkinson family gene expression and protein levels in LUAD, utilising multiple databases. Least absolute shrinkage and selection operator (LASSO) regression was used to construct a prognostic model based on the TCGA-LUAD cohort. We validated the model in external GEO cohorts. Immune cell infiltration was compared between risk groups, and GEO data was used to explore the model’s predictive ability for LUAD treatment response. Nearly all Parkinson family genes exhibited significant differential expression between LUAD and normal tissues. LASSO regression confirmed that our seven Parkinson family gene-based signature had excellent prognostic performance for LUAD, as validated in three GEO cohorts. The high-risk group was clearly associated with low tumour immune cell infiltration, suggesting that immunotherapy may not be an optimal treatment choice. This is the first Parkinson family gene-based model for the prediction of LUAD prognosis and treatment outcome. The association of these genes with poor prognosis and low immune infiltration requires further investigation. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8488091/ /pubmed/34616772 http://dx.doi.org/10.3389/fmolb.2021.735263 Text en Copyright © 2021 Li, Lu, Zhang, Liu, Zhou, Deng, Qiu, Chen, Li, Yang, Zheng and Dai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Li, Yanqi
Lu, Xiao
Zhang, Jiao
Liu, Quanxing
Zhou, Dong
Deng, Xufeng
Qiu, Yuan
Chen, Qian
Li, Manyuan
Yang, Guixue
Zheng, Hong
Dai, Jigang
Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma
title Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma
title_full Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma
title_fullStr Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma
title_full_unstemmed Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma
title_short Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma
title_sort significance of parkinson family genes in the prognosis and treatment outcome prediction for lung adenocarcinoma
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488091/
https://www.ncbi.nlm.nih.gov/pubmed/34616772
http://dx.doi.org/10.3389/fmolb.2021.735263
work_keys_str_mv AT liyanqi significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT luxiao significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT zhangjiao significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT liuquanxing significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT zhoudong significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT dengxufeng significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT qiuyuan significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT chenqian significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT limanyuan significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT yangguixue significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT zhenghong significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma
AT daijigang significanceofparkinsonfamilygenesintheprognosisandtreatmentoutcomepredictionforlungadenocarcinoma