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Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas
Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, upon light-induced injury, photoreceptor regeneration is achieved through reprogramming of Müller glia cells, which proliferate and give ris...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488126/ https://www.ncbi.nlm.nih.gov/pubmed/34616723 http://dx.doi.org/10.3389/fcell.2021.667796 |
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author | Lourenço, Raquel Brandão, Ana S. Borbinha, Jorge Gorgulho, Rita Jacinto, António |
author_facet | Lourenço, Raquel Brandão, Ana S. Borbinha, Jorge Gorgulho, Rita Jacinto, António |
author_sort | Lourenço, Raquel |
collection | PubMed |
description | Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, upon light-induced injury, photoreceptor regeneration is achieved through reprogramming of Müller glia cells, which proliferate and give rise to a self-renewing population of progenitors that migrate to the lesion site to differentiate into the new photoreceptors. The Hippo pathway effector YAP was recently implicated in the response to damage in the retina, but how this transcription coactivator is integrated into the signaling network regulating Müller glia reprogramming has not yet been explored. Here, we show that Yap is required in Müller glia to engage their response to a lesion by regulating their cell cycle reentry and progenitor cell formation, contributing to the differentiation of new photoreceptors. We propose that this regulation is accomplished through a lin28a–ascl1a-dependent mechanism, bona fide Müller glia-reprogramming factors. Overall, this study presents Yap as a key regulator of zebrafish Müller glia reprogramming and consequently retina regeneration upon injury. |
format | Online Article Text |
id | pubmed-8488126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84881262021-10-05 Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas Lourenço, Raquel Brandão, Ana S. Borbinha, Jorge Gorgulho, Rita Jacinto, António Front Cell Dev Biol Cell and Developmental Biology Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, upon light-induced injury, photoreceptor regeneration is achieved through reprogramming of Müller glia cells, which proliferate and give rise to a self-renewing population of progenitors that migrate to the lesion site to differentiate into the new photoreceptors. The Hippo pathway effector YAP was recently implicated in the response to damage in the retina, but how this transcription coactivator is integrated into the signaling network regulating Müller glia reprogramming has not yet been explored. Here, we show that Yap is required in Müller glia to engage their response to a lesion by regulating their cell cycle reentry and progenitor cell formation, contributing to the differentiation of new photoreceptors. We propose that this regulation is accomplished through a lin28a–ascl1a-dependent mechanism, bona fide Müller glia-reprogramming factors. Overall, this study presents Yap as a key regulator of zebrafish Müller glia reprogramming and consequently retina regeneration upon injury. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8488126/ /pubmed/34616723 http://dx.doi.org/10.3389/fcell.2021.667796 Text en Copyright © 2021 Lourenço, Brandão, Borbinha, Gorgulho and Jacinto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Lourenço, Raquel Brandão, Ana S. Borbinha, Jorge Gorgulho, Rita Jacinto, António Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas |
title | Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas |
title_full | Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas |
title_fullStr | Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas |
title_full_unstemmed | Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas |
title_short | Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas |
title_sort | yap regulates müller glia reprogramming in damaged zebrafish retinas |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488126/ https://www.ncbi.nlm.nih.gov/pubmed/34616723 http://dx.doi.org/10.3389/fcell.2021.667796 |
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