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Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

The controlling nutritional status (CONUT) score assesses nutritional status and is associated with short- and long-term prognoses in some diseases, but the significance of the CONUT score for the prediction of in-hospital mortality in older adults is unknown. The purpose was to determine the import...

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Autores principales: Liu, Chengyu, Zhu, Mingwei, Yang, Xin, Cui, Hongyuan, Li, Zijian, Wei, Junmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488127/
https://www.ncbi.nlm.nih.gov/pubmed/34616765
http://dx.doi.org/10.3389/fnut.2021.738045
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author Liu, Chengyu
Zhu, Mingwei
Yang, Xin
Cui, Hongyuan
Li, Zijian
Wei, Junmin
author_facet Liu, Chengyu
Zhu, Mingwei
Yang, Xin
Cui, Hongyuan
Li, Zijian
Wei, Junmin
author_sort Liu, Chengyu
collection PubMed
description The controlling nutritional status (CONUT) score assesses nutritional status and is associated with short- and long-term prognoses in some diseases, but the significance of the CONUT score for the prediction of in-hospital mortality in older adults is unknown. The purpose was to determine the importance of the CONUT score for the prediction of in-hospital mortality, short-term complications, length of hospital stay, and hospital costs in older adults. Our retrospective cohort study analyzed data from 11,795 older adult patients from two multicenter cohort studies. We performed receiver operating characteristic curve analysis using in-hospital mortality as the endpoint and determined the appropriate CONUT score cut-off by the Youden index. The patients were divided into two high and low groups according to the CONUT cut-off value, and the differences in clinical characteristics and in-hospital clinical outcomes between the two groups were compared. We compared the accuracy of the CONUT score and other nutrition-related tools in predicting in-hospital mortality by calculating the area under the receiver operating characteristic curve and performed univariate and multivariate analyses of predictors of in-hospital mortality. Among all the patients, 178 (1.5%) patients experienced in-hospital death. The optimal cut-off values was 5.5 for the CONUT score. The high CONUT group had a higher incidence of short-term complications and prolonged hospital stay than the low CONUT group (CONUT score <6), but hospital costs were not significantly higher. The CONUT score had the highest predictive ability for in-hospital mortality among the five nutrition-related parameters compared. Multivariate analysis showed that a high CONUT score (CONUT score ≥ 6) was an independent predictor of in-hospital mortality. In conclusion, the present study demonstrated that the CONUT score could be used to predict in-hospital mortality in older adults.
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spelling pubmed-84881272021-10-05 Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients Liu, Chengyu Zhu, Mingwei Yang, Xin Cui, Hongyuan Li, Zijian Wei, Junmin Front Nutr Nutrition The controlling nutritional status (CONUT) score assesses nutritional status and is associated with short- and long-term prognoses in some diseases, but the significance of the CONUT score for the prediction of in-hospital mortality in older adults is unknown. The purpose was to determine the importance of the CONUT score for the prediction of in-hospital mortality, short-term complications, length of hospital stay, and hospital costs in older adults. Our retrospective cohort study analyzed data from 11,795 older adult patients from two multicenter cohort studies. We performed receiver operating characteristic curve analysis using in-hospital mortality as the endpoint and determined the appropriate CONUT score cut-off by the Youden index. The patients were divided into two high and low groups according to the CONUT cut-off value, and the differences in clinical characteristics and in-hospital clinical outcomes between the two groups were compared. We compared the accuracy of the CONUT score and other nutrition-related tools in predicting in-hospital mortality by calculating the area under the receiver operating characteristic curve and performed univariate and multivariate analyses of predictors of in-hospital mortality. Among all the patients, 178 (1.5%) patients experienced in-hospital death. The optimal cut-off values was 5.5 for the CONUT score. The high CONUT group had a higher incidence of short-term complications and prolonged hospital stay than the low CONUT group (CONUT score <6), but hospital costs were not significantly higher. The CONUT score had the highest predictive ability for in-hospital mortality among the five nutrition-related parameters compared. Multivariate analysis showed that a high CONUT score (CONUT score ≥ 6) was an independent predictor of in-hospital mortality. In conclusion, the present study demonstrated that the CONUT score could be used to predict in-hospital mortality in older adults. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8488127/ /pubmed/34616765 http://dx.doi.org/10.3389/fnut.2021.738045 Text en Copyright © 2021 Liu, Zhu, Yang, Cui, Li and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Liu, Chengyu
Zhu, Mingwei
Yang, Xin
Cui, Hongyuan
Li, Zijian
Wei, Junmin
Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients
title Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients
title_full Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients
title_fullStr Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients
title_full_unstemmed Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients
title_short Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients
title_sort controlling nutritional status score as a predictive marker of in-hospital mortality in older adult patients
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488127/
https://www.ncbi.nlm.nih.gov/pubmed/34616765
http://dx.doi.org/10.3389/fnut.2021.738045
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