Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases

Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases. Objective: In thi...

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Detalles Bibliográficos
Autores principales: Liu, Caojie, Kang, Ning, Guo, Yuchen, Gong, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488160/
https://www.ncbi.nlm.nih.gov/pubmed/34616726
http://dx.doi.org/10.3389/fcell.2021.710203
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author Liu, Caojie
Kang, Ning
Guo, Yuchen
Gong, Ping
author_facet Liu, Caojie
Kang, Ning
Guo, Yuchen
Gong, Ping
author_sort Liu, Caojie
collection PubMed
description Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases. Objective: In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers. Conclusion: CHD proteins play a crucial role in stem cell differentiation and human diseases.
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spelling pubmed-84881602021-10-05 Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases Liu, Caojie Kang, Ning Guo, Yuchen Gong, Ping Front Cell Dev Biol Cell and Developmental Biology Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases. Objective: In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers. Conclusion: CHD proteins play a crucial role in stem cell differentiation and human diseases. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8488160/ /pubmed/34616726 http://dx.doi.org/10.3389/fcell.2021.710203 Text en Copyright © 2021 Liu, Kang, Guo and Gong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Caojie
Kang, Ning
Guo, Yuchen
Gong, Ping
Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases
title Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases
title_full Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases
title_fullStr Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases
title_full_unstemmed Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases
title_short Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases
title_sort advances in chromodomain helicase dna-binding (chd) proteins regulating stem cell differentiation and human diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488160/
https://www.ncbi.nlm.nih.gov/pubmed/34616726
http://dx.doi.org/10.3389/fcell.2021.710203
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AT guoyuchen advancesinchromodomainhelicasednabindingchdproteinsregulatingstemcelldifferentiationandhumandiseases
AT gongping advancesinchromodomainhelicasednabindingchdproteinsregulatingstemcelldifferentiationandhumandiseases

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