Cargando…
A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo
Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level remains rudimentary. in vitro molecular biology and bioinformatics approaches have...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488174/ https://www.ncbi.nlm.nih.gov/pubmed/34616758 http://dx.doi.org/10.3389/fmed.2021.740615 |
_version_ | 1784578102406414336 |
---|---|
author | Suchacki, Karla J. Alcaide-Corral, Carlos J. Nimale, Samah Macaskill, Mark G. Stimson, Roland H. Farquharson, Colin Freeman, Tom C. Tavares, Adriana A. S. |
author_facet | Suchacki, Karla J. Alcaide-Corral, Carlos J. Nimale, Samah Macaskill, Mark G. Stimson, Roland H. Farquharson, Colin Freeman, Tom C. Tavares, Adriana A. S. |
author_sort | Suchacki, Karla J. |
collection | PubMed |
description | Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level remains rudimentary. in vitro molecular biology and bioinformatics approaches have frequently been used to understand the mechanistic changes underlying disease at the cell level, however, these approaches lack the capability to interrogate dynamic multi-bone metabolic interactions in vivo. Here we present a novel and integrative approach to understand complex bone metabolic interactions in vivo using total-body positron emission tomography (PET) network analysis of murine (18)F-FDG scans, as a biomarker of glucose metabolism in bones. In this report we show that different bones within the skeleton have a unique glucose metabolism and form a complex metabolic network, which could not be identified using single tissue simplistic PET standard uptake values analysis. The application of our approach could reveal new physiological and pathological tissue interactions beyond skeletal metabolism, due to PET radiotracers diversity and the advent of clinical total-body PET systems. |
format | Online Article Text |
id | pubmed-8488174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84881742021-10-05 A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo Suchacki, Karla J. Alcaide-Corral, Carlos J. Nimale, Samah Macaskill, Mark G. Stimson, Roland H. Farquharson, Colin Freeman, Tom C. Tavares, Adriana A. S. Front Med (Lausanne) Medicine Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level remains rudimentary. in vitro molecular biology and bioinformatics approaches have frequently been used to understand the mechanistic changes underlying disease at the cell level, however, these approaches lack the capability to interrogate dynamic multi-bone metabolic interactions in vivo. Here we present a novel and integrative approach to understand complex bone metabolic interactions in vivo using total-body positron emission tomography (PET) network analysis of murine (18)F-FDG scans, as a biomarker of glucose metabolism in bones. In this report we show that different bones within the skeleton have a unique glucose metabolism and form a complex metabolic network, which could not be identified using single tissue simplistic PET standard uptake values analysis. The application of our approach could reveal new physiological and pathological tissue interactions beyond skeletal metabolism, due to PET radiotracers diversity and the advent of clinical total-body PET systems. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8488174/ /pubmed/34616758 http://dx.doi.org/10.3389/fmed.2021.740615 Text en Copyright © 2021 Suchacki, Alcaide-Corral, Nimale, Macaskill, Stimson, Farquharson, Freeman and Tavares. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Suchacki, Karla J. Alcaide-Corral, Carlos J. Nimale, Samah Macaskill, Mark G. Stimson, Roland H. Farquharson, Colin Freeman, Tom C. Tavares, Adriana A. S. A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo |
title | A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo |
title_full | A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo |
title_fullStr | A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo |
title_full_unstemmed | A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo |
title_short | A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo |
title_sort | systems-level analysis of total-body pet data reveals complex skeletal metabolism networks in vivo |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488174/ https://www.ncbi.nlm.nih.gov/pubmed/34616758 http://dx.doi.org/10.3389/fmed.2021.740615 |
work_keys_str_mv | AT suchackikarlaj asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT alcaidecorralcarlosj asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT nimalesamah asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT macaskillmarkg asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT stimsonrolandh asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT farquharsoncolin asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT freemantomc asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT tavaresadrianaas asystemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT suchackikarlaj systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT alcaidecorralcarlosj systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT nimalesamah systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT macaskillmarkg systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT stimsonrolandh systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT farquharsoncolin systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT freemantomc systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo AT tavaresadrianaas systemslevelanalysisoftotalbodypetdatarevealscomplexskeletalmetabolismnetworksinvivo |