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Chemical Inhibition of Apurinic-Apyrimidinic Endonuclease 1 Redox and DNA Repair Functions Affects the Inflammatory Response via Different but Overlapping Mechanisms

The presence of oxidized DNA lesions, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and apurinic/apyrimidinic sites (AP sites), has been described as epigenetic signals that are involved in gene expression control. In mammals, Apurinic-apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) is the main...

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Detalles Bibliográficos
Autores principales:	Oliveira, Thais Teixeira, Fontes-Dantas, Fabrícia Lima, de Medeiros Oliveira, Rayssa Karla, Pinheiro, Daniele Maria Lopes, Coutinho, Leonam Gomes, da Silva, Vandeclecio Lira, de Souza, Sandro José, Agnez-Lima, Lucymara Fassarella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488223/ https://www.ncbi.nlm.nih.gov/pubmed/34616737 http://dx.doi.org/10.3389/fcell.2021.731588

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