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Calcium and Spike Timing-Dependent Plasticity

Since its discovery, spike timing-dependent synaptic plasticity (STDP) has been thought to be a primary mechanism underlying the brain’s ability to learn and to form new memories. However, despite the enormous interest in both the experimental and theoretical neuroscience communities in activity-dep...

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Detalles Bibliográficos
Autores principales: Inglebert, Yanis, Debanne, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488271/
https://www.ncbi.nlm.nih.gov/pubmed/34616278
http://dx.doi.org/10.3389/fncel.2021.727336
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author Inglebert, Yanis
Debanne, Dominique
author_facet Inglebert, Yanis
Debanne, Dominique
author_sort Inglebert, Yanis
collection PubMed
description Since its discovery, spike timing-dependent synaptic plasticity (STDP) has been thought to be a primary mechanism underlying the brain’s ability to learn and to form new memories. However, despite the enormous interest in both the experimental and theoretical neuroscience communities in activity-dependent plasticity, it is still unclear whether plasticity rules inferred from in vitro experiments apply to in vivo conditions. Among the multiple reasons why plasticity rules in vivo might differ significantly from in vitro studies is that extracellular calcium concentration use in most studies is higher than concentrations estimated in vivo. STDP, like many forms of long-term synaptic plasticity, strongly depends on intracellular calcium influx for its induction. Here, we discuss the importance of considering physiological levels of extracellular calcium concentration to study functional plasticity.
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spelling pubmed-84882712021-10-05 Calcium and Spike Timing-Dependent Plasticity Inglebert, Yanis Debanne, Dominique Front Cell Neurosci Cellular Neuroscience Since its discovery, spike timing-dependent synaptic plasticity (STDP) has been thought to be a primary mechanism underlying the brain’s ability to learn and to form new memories. However, despite the enormous interest in both the experimental and theoretical neuroscience communities in activity-dependent plasticity, it is still unclear whether plasticity rules inferred from in vitro experiments apply to in vivo conditions. Among the multiple reasons why plasticity rules in vivo might differ significantly from in vitro studies is that extracellular calcium concentration use in most studies is higher than concentrations estimated in vivo. STDP, like many forms of long-term synaptic plasticity, strongly depends on intracellular calcium influx for its induction. Here, we discuss the importance of considering physiological levels of extracellular calcium concentration to study functional plasticity. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8488271/ /pubmed/34616278 http://dx.doi.org/10.3389/fncel.2021.727336 Text en Copyright © 2021 Inglebert and Debanne. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Inglebert, Yanis
Debanne, Dominique
Calcium and Spike Timing-Dependent Plasticity
title Calcium and Spike Timing-Dependent Plasticity
title_full Calcium and Spike Timing-Dependent Plasticity
title_fullStr Calcium and Spike Timing-Dependent Plasticity
title_full_unstemmed Calcium and Spike Timing-Dependent Plasticity
title_short Calcium and Spike Timing-Dependent Plasticity
title_sort calcium and spike timing-dependent plasticity
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488271/
https://www.ncbi.nlm.nih.gov/pubmed/34616278
http://dx.doi.org/10.3389/fncel.2021.727336
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