Generation of an orthotopic mouse model to study colorectal cancer metastasis

This protocol describes the generation of a mouse colorectal cancer (CRC) model to study the mechanism of CRC growth and metastasis. Compared to existing protocols, this protocol is mainly to improve the incidence of metastasis. The major advantage of this model is that it mimics the process of clin...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Liwen, Bu, Pengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488307/
https://www.ncbi.nlm.nih.gov/pubmed/34632412
http://dx.doi.org/10.1016/j.xpro.2021.100792
_version_ 1784578135775248384
author Zhang, Liwen
Bu, Pengcheng
author_facet Zhang, Liwen
Bu, Pengcheng
author_sort Zhang, Liwen
collection PubMed
description This protocol describes the generation of a mouse colorectal cancer (CRC) model to study the mechanism of CRC growth and metastasis. Compared to existing protocols, this protocol is mainly to improve the incidence of metastasis. The major advantage of this model is that it mimics the process of clinical CRC metastasis. Thus, it can be used to study different stages of CRC progression and to identify molecular markers or therapeutic targets. The limitation is the difficulty of performing the operation. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2021).
format Online
Article
Text
id pubmed-8488307
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-84883072021-10-08 Generation of an orthotopic mouse model to study colorectal cancer metastasis Zhang, Liwen Bu, Pengcheng STAR Protoc Protocol This protocol describes the generation of a mouse colorectal cancer (CRC) model to study the mechanism of CRC growth and metastasis. Compared to existing protocols, this protocol is mainly to improve the incidence of metastasis. The major advantage of this model is that it mimics the process of clinical CRC metastasis. Thus, it can be used to study different stages of CRC progression and to identify molecular markers or therapeutic targets. The limitation is the difficulty of performing the operation. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2021). Elsevier 2021-09-27 /pmc/articles/PMC8488307/ /pubmed/34632412 http://dx.doi.org/10.1016/j.xpro.2021.100792 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Zhang, Liwen
Bu, Pengcheng
Generation of an orthotopic mouse model to study colorectal cancer metastasis
title Generation of an orthotopic mouse model to study colorectal cancer metastasis
title_full Generation of an orthotopic mouse model to study colorectal cancer metastasis
title_fullStr Generation of an orthotopic mouse model to study colorectal cancer metastasis
title_full_unstemmed Generation of an orthotopic mouse model to study colorectal cancer metastasis
title_short Generation of an orthotopic mouse model to study colorectal cancer metastasis
title_sort generation of an orthotopic mouse model to study colorectal cancer metastasis
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488307/
https://www.ncbi.nlm.nih.gov/pubmed/34632412
http://dx.doi.org/10.1016/j.xpro.2021.100792
work_keys_str_mv AT zhangliwen generationofanorthotopicmousemodeltostudycolorectalcancermetastasis
AT bupengcheng generationofanorthotopicmousemodeltostudycolorectalcancermetastasis

Ejemplares similares