Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8(+) T Cell Proliferation

Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for NK cells is emerging in diverse models of viral infection, transplantation, and...

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Detalles Bibliográficos
Autores principales: Sierra, Jessica M., Secchiari, Florencia, Nuñez, Sol Y., Iraolagoitia, Ximena L. Raffo, Ziblat, Andrea, Friedrich, Adrián D., Regge, María V., Santilli, M. Cecilia, Torres, Nicolás I., Gantov, Mariana, Trotta, Aldana, Ameri, Carlos, Vitagliano, Gonzalo, Pita, Hernando Ríos, Rico, Luis, Rovegno, Agustín, Richards, Nicolás, Domaica, Carolina I., Zwirner, Norberto W., Fuertes, Mercedes B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488336/
https://www.ncbi.nlm.nih.gov/pubmed/34616407
http://dx.doi.org/10.3389/fimmu.2021.745939

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