Approaches to Establishing Tolerance in Immune Mediated Diseases

The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune T...

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Autores principales: Huffaker, Michelle F., Sanda, Srinath, Chandran, Sindhu, Chung, Sharon A., St. Clair, E. William, Nepom, Gerald T., Smilek, Dawn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488342/
https://www.ncbi.nlm.nih.gov/pubmed/34616405
http://dx.doi.org/10.3389/fimmu.2021.744804
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author Huffaker, Michelle F.
Sanda, Srinath
Chandran, Sindhu
Chung, Sharon A.
St. Clair, E. William
Nepom, Gerald T.
Smilek, Dawn E.
author_facet Huffaker, Michelle F.
Sanda, Srinath
Chandran, Sindhu
Chung, Sharon A.
St. Clair, E. William
Nepom, Gerald T.
Smilek, Dawn E.
author_sort Huffaker, Michelle F.
collection PubMed
description The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance.
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spelling pubmed-84883422021-10-05 Approaches to Establishing Tolerance in Immune Mediated Diseases Huffaker, Michelle F. Sanda, Srinath Chandran, Sindhu Chung, Sharon A. St. Clair, E. William Nepom, Gerald T. Smilek, Dawn E. Front Immunol Immunology The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8488342/ /pubmed/34616405 http://dx.doi.org/10.3389/fimmu.2021.744804 Text en Copyright © 2021 Huffaker, Sanda, Chandran, Chung, St. Clair, Nepom and Smilek https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huffaker, Michelle F.
Sanda, Srinath
Chandran, Sindhu
Chung, Sharon A.
St. Clair, E. William
Nepom, Gerald T.
Smilek, Dawn E.
Approaches to Establishing Tolerance in Immune Mediated Diseases
title Approaches to Establishing Tolerance in Immune Mediated Diseases
title_full Approaches to Establishing Tolerance in Immune Mediated Diseases
title_fullStr Approaches to Establishing Tolerance in Immune Mediated Diseases
title_full_unstemmed Approaches to Establishing Tolerance in Immune Mediated Diseases
title_short Approaches to Establishing Tolerance in Immune Mediated Diseases
title_sort approaches to establishing tolerance in immune mediated diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488342/
https://www.ncbi.nlm.nih.gov/pubmed/34616405
http://dx.doi.org/10.3389/fimmu.2021.744804
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