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Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting donor-derived human leukocyte antigen (HLA) is a promising strategy to promote transplant tolerance. Here, we describe an anti-HLA-A2 CAR (A2-CAR) generated by grafting the complementarity-determining...

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Detalles Bibliográficos
Autores principales:	Muller, Yannick D., Ferreira, Leonardo M. R., Ronin, Emilie, Ho, Patrick, Nguyen, Vinh, Faleo, Gaetano, Zhou, Yu, Lee, Karim, Leung, Kevin K., Skartsis, Nikolaos, Kaul, Anupurna M., Mulder, Arend, Claas, Frans H. J., Wells, James A., Bluestone, Jeffrey A., Tang, Qizhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488356/ https://www.ncbi.nlm.nih.gov/pubmed/34616392 http://dx.doi.org/10.3389/fimmu.2021.686439

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