Somatic Mutations in Oncogenes Are in Chronic Myeloid Leukemia Acquired De Novo via Deregulated Base-Excision Repair and Alternative Non-Homologous End Joining

Somatic mutations are a common molecular mechanism through which chronic myeloid leukemia (CML) cells acquire resistance to tyrosine kinase inhibitors (TKIs) therapy. While most of the mutations in the kinase domain of BCR-ABL1 can be successfully managed, the recurrent somatic mutations in other ge...

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Detalles Bibliográficos
Autores principales: Curik, Nikola, Polivkova, Vaclava, Burda, Pavel, Koblihova, Jitka, Laznicka, Adam, Kalina, Tomas, Kanderova, Veronika, Brezinova, Jana, Ransdorfova, Sarka, Karasova, Dominika, Rejlova, Katerina, Bakardjieva, Marina, Kuzilkova, Daniela, Kundrat, David, Linhartova, Jana, Klamova, Hana, Salek, Cyril, Klener, Pavel, Hrusak, Ondrej, Machova Polakova, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488388/
https://www.ncbi.nlm.nih.gov/pubmed/34616685
http://dx.doi.org/10.3389/fonc.2021.744373

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