Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient

Vitiligo is an autoimmune skin disease presenting with areas of depigmentation. Recent reports suggest that Janus kinase (JAK) inhibitors may be an effective therapy. In this case report, we show our experience with an adolescent patient with a long history of generalized and refractory vitiligo, fo...

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Detalles Bibliográficos
Autores principales: Berbert Ferreira, Sineida, Berbert Ferreira, Rachel, Neves Neto, Afonso Cesar, Assef, Silvana Martins Caparroz, Scheinberg, Morton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488419/
https://www.ncbi.nlm.nih.gov/pubmed/34703426
http://dx.doi.org/10.1159/000513938
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author Berbert Ferreira, Sineida
Berbert Ferreira, Rachel
Neves Neto, Afonso Cesar
Assef, Silvana Martins Caparroz
Scheinberg, Morton
author_facet Berbert Ferreira, Sineida
Berbert Ferreira, Rachel
Neves Neto, Afonso Cesar
Assef, Silvana Martins Caparroz
Scheinberg, Morton
author_sort Berbert Ferreira, Sineida
collection PubMed
description Vitiligo is an autoimmune skin disease presenting with areas of depigmentation. Recent reports suggest that Janus kinase (JAK) inhibitors may be an effective therapy. In this case report, we show our experience with an adolescent patient with a long history of generalized and refractory vitiligo, for which treatment with topical tofacitinib, a JAK inhibitor, associated with phototherapy for 9 months, resulted in near complete repigmentation.
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spelling pubmed-84884192021-10-25 Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient Berbert Ferreira, Sineida Berbert Ferreira, Rachel Neves Neto, Afonso Cesar Assef, Silvana Martins Caparroz Scheinberg, Morton Case Rep Dermatol Single Case Vitiligo is an autoimmune skin disease presenting with areas of depigmentation. Recent reports suggest that Janus kinase (JAK) inhibitors may be an effective therapy. In this case report, we show our experience with an adolescent patient with a long history of generalized and refractory vitiligo, for which treatment with topical tofacitinib, a JAK inhibitor, associated with phototherapy for 9 months, resulted in near complete repigmentation. S. Karger AG 2021-04-01 /pmc/articles/PMC8488419/ /pubmed/34703426 http://dx.doi.org/10.1159/000513938 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Berbert Ferreira, Sineida
Berbert Ferreira, Rachel
Neves Neto, Afonso Cesar
Assef, Silvana Martins Caparroz
Scheinberg, Morton
Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient
title Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient
title_full Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient
title_fullStr Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient
title_full_unstemmed Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient
title_short Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient
title_sort topical tofacitinib: a janus kinase inhibitor for the treatment of vitiligo in an adolescent patient
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488419/
https://www.ncbi.nlm.nih.gov/pubmed/34703426
http://dx.doi.org/10.1159/000513938
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