Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion

We present a rare case of KRAS keratinocytic epidermal nevus syndrome with lymphatic malformation, responsive to treatment with sirolimus, an mTOR inhibitor. A brief review of the current literature regarding sirolimus use in vascular malformations, lymphatic malformations, regional overgrowth syndr...

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Detalles Bibliográficos
Autores principales: Sideris, Emily, Tng, Er Tsing Vivian, Chee, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case and Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488422/
https://www.ncbi.nlm.nih.gov/pubmed/34703427
http://dx.doi.org/10.1159/000515247
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author Sideris, Emily
Tng, Er Tsing Vivian
Chee, Paul
author_facet Sideris, Emily
Tng, Er Tsing Vivian
Chee, Paul
author_sort Sideris, Emily
collection PubMed
description We present a rare case of KRAS keratinocytic epidermal nevus syndrome with lymphatic malformation, responsive to treatment with sirolimus, an mTOR inhibitor. A brief review of the current literature regarding sirolimus use in vascular malformations, lymphatic malformations, regional overgrowth syndromes, and RASopathies is discussed.
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spelling pubmed-84884222021-10-25 Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion Sideris, Emily Tng, Er Tsing Vivian Chee, Paul Case Rep Dermatol Case and Review We present a rare case of KRAS keratinocytic epidermal nevus syndrome with lymphatic malformation, responsive to treatment with sirolimus, an mTOR inhibitor. A brief review of the current literature regarding sirolimus use in vascular malformations, lymphatic malformations, regional overgrowth syndromes, and RASopathies is discussed. S. Karger AG 2021-04-01 /pmc/articles/PMC8488422/ /pubmed/34703427 http://dx.doi.org/10.1159/000515247 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case and Review
Sideris, Emily
Tng, Er Tsing Vivian
Chee, Paul
Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion
title Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion
title_full Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion
title_fullStr Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion
title_full_unstemmed Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion
title_short Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion
title_sort lymphatic malformation responsive to sirolimus in keratinocytic epidermal nevus syndrome with kras mutation: a case and brief literature discussion
topic Case and Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488422/
https://www.ncbi.nlm.nih.gov/pubmed/34703427
http://dx.doi.org/10.1159/000515247
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AT cheepaul lymphaticmalformationresponsivetosirolimusinkeratinocyticepidermalnevussyndromewithkrasmutationacaseandbriefliteraturediscussion

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