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Data on RNA-seq analysis of Drosophila melanogaster during ageing
Ageing is defined as gradual decline of physiological, cellular and molecular state of an organism with time. The age-associated cell dysfunctions usually cause chronic diseases such as diabetes, cancers and other age-related diseases. Many of the genes and pathways involved in ageing are conserved...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488473/ https://www.ncbi.nlm.nih.gov/pubmed/34632013 http://dx.doi.org/10.1016/j.dib.2021.107413 |
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author | Bajgiran, Morteza Azlan, Azali Shamsuddin, Shaharum Azzam, Ghows Halim, Mardani Abdul |
author_facet | Bajgiran, Morteza Azlan, Azali Shamsuddin, Shaharum Azzam, Ghows Halim, Mardani Abdul |
author_sort | Bajgiran, Morteza |
collection | PubMed |
description | Ageing is defined as gradual decline of physiological, cellular and molecular state of an organism with time. The age-associated cell dysfunctions usually cause chronic diseases such as diabetes, cancers and other age-related diseases. Many of the genes and pathways involved in ageing are conserved in different species. These genes and pathways have been categorised into nine cellular and molecular hallmarks, namely, genomic instability, telomere attrition, loss of proteostasis, mitochondrial dysfunction, epigenetic alterations, deregulated nutrient sensing, stem cell exhaustion, cellular senescence and altered intercellular communication. Despite countless studies on ageing, the molecular mechanism of ageing is poorly understood. Here, we performed genome wide transcriptome mapping of ageing process in D. melanogaster. In which, transcriptomic analysis conducted on the 1 day and 60 days flies. Illumina Hiseq platform were used to generate raw data. Afterwards, further analysis including differential expression analysis, GO classification and KEGG pathway enrichment analysis were performed. The raw data were uploaded to SRA database and the BioProject ID is PRJNA718442. These data provide the basis for future research in order to discover the genes and pathways involved in ageing. |
format | Online Article Text |
id | pubmed-8488473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84884732021-10-08 Data on RNA-seq analysis of Drosophila melanogaster during ageing Bajgiran, Morteza Azlan, Azali Shamsuddin, Shaharum Azzam, Ghows Halim, Mardani Abdul Data Brief Data Article Ageing is defined as gradual decline of physiological, cellular and molecular state of an organism with time. The age-associated cell dysfunctions usually cause chronic diseases such as diabetes, cancers and other age-related diseases. Many of the genes and pathways involved in ageing are conserved in different species. These genes and pathways have been categorised into nine cellular and molecular hallmarks, namely, genomic instability, telomere attrition, loss of proteostasis, mitochondrial dysfunction, epigenetic alterations, deregulated nutrient sensing, stem cell exhaustion, cellular senescence and altered intercellular communication. Despite countless studies on ageing, the molecular mechanism of ageing is poorly understood. Here, we performed genome wide transcriptome mapping of ageing process in D. melanogaster. In which, transcriptomic analysis conducted on the 1 day and 60 days flies. Illumina Hiseq platform were used to generate raw data. Afterwards, further analysis including differential expression analysis, GO classification and KEGG pathway enrichment analysis were performed. The raw data were uploaded to SRA database and the BioProject ID is PRJNA718442. These data provide the basis for future research in order to discover the genes and pathways involved in ageing. Elsevier 2021-09-22 /pmc/articles/PMC8488473/ /pubmed/34632013 http://dx.doi.org/10.1016/j.dib.2021.107413 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Data Article Bajgiran, Morteza Azlan, Azali Shamsuddin, Shaharum Azzam, Ghows Halim, Mardani Abdul Data on RNA-seq analysis of Drosophila melanogaster during ageing |
title | Data on RNA-seq analysis of Drosophila melanogaster during ageing |
title_full | Data on RNA-seq analysis of Drosophila melanogaster during ageing |
title_fullStr | Data on RNA-seq analysis of Drosophila melanogaster during ageing |
title_full_unstemmed | Data on RNA-seq analysis of Drosophila melanogaster during ageing |
title_short | Data on RNA-seq analysis of Drosophila melanogaster during ageing |
title_sort | data on rna-seq analysis of drosophila melanogaster during ageing |
topic | Data Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488473/ https://www.ncbi.nlm.nih.gov/pubmed/34632013 http://dx.doi.org/10.1016/j.dib.2021.107413 |
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