Cargando…

Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer

Treatment for advanced gastric cancer is challenging. Epidermal growth factor receptor (EGFR) contributes to the proliferation and development of gastric cancer (GC), and its overexpression is associated with unfavorable prognosis in GC. Cetuximab, a monoclonal antibody targeting EGFR, failed to imp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Huanrong, Wu, Jingjing, Zhou, Minyu, Wu, Jianhua, Wu, Zhenzhen, Lin, Li, Huang, Na, Liao, Wangjun, Sun, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488517/ https://www.ncbi.nlm.nih.gov/pubmed/34590499 http://dx.doi.org/10.1177/15347354211045349

Ejemplares similares

MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling
por: Huang, Na, et al.
Publicado: (2015)

Impact of liver tumor percutaneous radiofrequency ablation on circulating tumor cells
por: Li, Yang, et al.
Publicado: (2018)

Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2‐positive gastric cancer
por: Hu, Xingbin, et al.
Publicado: (2023)

Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer
por: DUAN, JIANGMAN, et al.
Publicado: (2016)

XB130 promotes proliferation and invasion of gastric cancer cells
por: Shi, Min, et al.
Publicado: (2014)

Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer
por: Wang, Qian, et al.
Publicado: (2014)

Targeting glutamine uptake in AML
por: Jacque, Nathalie, et al.
Publicado: (2014)

MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression
por: Duan, Jiangman, et al.
Publicado: (2017)

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake
por: Zhang, Pengcheng, et al.
Publicado: (2019)

Clinical significance of accurate identification of lymph node status in distant metastatic gastric cancer
por: Zhou, Rui, et al.
Publicado: (2015)

PET/CT Imaging of Activated Cancer-Associated Fibroblasts Predict Response to PD-1 Blockade in Gastric Cancer Patients
por: Rong, Xiaoxiang, et al.
Publicado: (2022)

AMPK phosphorylates PPARδ to mediate its stabilization, inhibit glucose and glutamine uptake and colon tumor growth
por: Ding, Jiajun, et al.
Publicado: (2021)

Corrigendum: PET/Ct Imaging of Activated Cancer-Associated Fibroblasts Predict Response to PD-1 Blockade in Gastric Cancer Patients
por: Rong, Xiaoxiang, et al.
Publicado: (2022)

Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine–Glutamate Cycle
por: Gandasi, Nikhil R., et al.
Publicado: (2021)

Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT3-ITD–Positive AML
por: Zavorka Thomas, Megan E., et al.
Publicado: (2021)

miR-577 Regulates TGF-β Induced Cancer Progression through a SDPR-Modulated Positive-Feedback Loop with ERK-NF-κB in Gastric Cancer
por: Luo, Yuhao, et al.
Publicado: (2019)

A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy
por: Zhang, Lianhai, et al.
Publicado: (2013)

MRI assessment of glutamine uptake correlates with the distribution of glutamine transporters and cancer stem cell markers
por: Seo, Yoojeong, et al.
Publicado: (2022)

Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate
por: Battista, Natalia, et al.
Publicado: (2002)

Restricting Glutamine Uptake Enhances NSCLC Sensitivity to Third-Generation EGFR-TKI Almonertinib
por: Liu, Yaming, et al.
Publicado: (2021)

Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis
por: Wu, Zhenzhen, et al.
Publicado: (2015)

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis
por: Ferreira, Carolina, et al.
Publicado: (2020)

Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction
por: McIntyre, Kirsty R., et al.
Publicado: (2020)

Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation
por: Kong, Youzi, et al.
Publicado: (2023)

Reclaiming the Balance: Blocking Glutamine Uptake to Restrain Pulmonary Fibrosis
por: Liu, Gang, et al.
Publicado: (2023)

Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism
por: Zhou, Wen-Jie, et al.
Publicado: (2019)

Resveratrol Sensitizes Colorectal Cancer Cells to Cetuximab by Connexin 43 Upregulation-Induced Akt Inhibition
por: Wang, Yijia, et al.
Publicado: (2020)

Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth
por: Ye, Jianxin, et al.
Publicado: (2018)

Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer
por: Wei, Li, et al.
Publicado: (2020)

Transgenic expression of plastidic glutamine synthetase increases nitrogen uptake and yield in wheat
por: Hu, Mengyun, et al.
Publicado: (2018)

Inhibition of ITGB1 enhance the anti-tumor effect of cetuximab in colorectal cancer cell
por: Yang, Xiaohui, et al.
Publicado: (2020)

FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer
por: Marzi, L, et al.
Publicado: (2016)

Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3(SPOP) E3 ligase in cancer cells
por: Zhou, Qiyin, et al.
Publicado: (2022)

ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma
por: Marshall, A D, et al.
Publicado: (2017)

Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model
por: Oizel, Kristell, et al.
Publicado: (2020)

Transgenic goats producing an improved version of cetuximab in milk
por: Laible, Götz, et al.
Publicado: (2020)

Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition
por: Lin, Yu-Wei, et al.
Publicado: (2017)

Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2
por: Wang, Lin, et al.
Publicado: (2015)

Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β(2)‐AR/MACC1 axis
por: Pan, Changqie, et al.
Publicado: (2021)

A multi-center phase II study and biomarker analysis of combined cetuximab and modified FOLFIRI as second-line treatment in patients with metastatic gastric cancer
por: Liu, Xin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cbd9mi4kgm4an35j7m9frjvtbv