The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels

Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 2 (SENP2)-deficient mice develop spontaneous seizures in early life because of a marked reduction in M currents, which regulate neuronal membrane excitability. We have previously shown that hyper-SUMOylation of the Kv7.2 and Kv7.3 channe...

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Detalles Bibliográficos
Autores principales: Chen, Xu, Zhang, Yuhong, Ren, Xiang, Su, Qi, Liu, Yan, Dang, Xing, Qin, Yuanyuan, Yang, Xinyi, Xing, Zhengcao, Shen, Yajie, Wang, Yaya, Bai, Zhantao, Yeh, Edward T.H., Wu, Hongmei, Qi, Yitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488601/
https://www.ncbi.nlm.nih.gov/pubmed/34509475
http://dx.doi.org/10.1016/j.jbc.2021.101183

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