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Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane

Mounting evidence suggests that the neuronal cell membrane is the main site of oligomer-mediated neuronal toxicity of amyloid- [Formula: see text] peptides in Alzheimer’s disease. To gain a detailed understanding of the mutual interference of amyloid- [Formula: see text] oligomers and the neuronal m...

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Detalles Bibliográficos
Autores principales: Fatafta, Hebah, Khaled, Mohammed, Owen, Michael C., Sayyed-Ahmad, Abdallah, Strodel, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488611/
https://www.ncbi.nlm.nih.gov/pubmed/34544868
http://dx.doi.org/10.1073/pnas.2106210118