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Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies

BACKGROUND: Individualized neoantigen-specific immunotherapy (iNeST) requires robustly expressed clonal neoantigens for efficacy, but tumor mutational heterogeneity, loss of neoantigen expression, and variable tissue sampling present challenges. It is assumed that clonal neoantigens are preferred ta...

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Detalles Bibliográficos
Autores principales:	Lo, Amy A, Wallace, Andrew, Oreper, Daniel, Lounsbury, Nicolas, Havnar, Charles, Pechuan-Jorge, Ximo, Wu, Thomas D, Bourgon, Richard, Jones, Ryan, Krogh, Katrina, Yang, Guang-Yu, Zill, Oliver A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488717/ https://www.ncbi.nlm.nih.gov/pubmed/34599029 http://dx.doi.org/10.1136/jitc-2021-003001

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