Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity

BACKGROUND: Natural killer group 2D (NKG2D) is an activating receptor of natural killer (NK) cells and other lymphocytes that mediates lysis of malignant cells through recognition of stress-induced ligands such as MICA and MICB. Such ligands are broadly expressed by cancer cells of various origins a...

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Detalles Bibliográficos
Autores principales: Zhang, Congcong, Röder, Jasmin, Scherer, Anne, Bodden, Malena, Pfeifer Serrahima, Jordi, Bhatti, Anita, Waldmann, Anja, Müller, Nina, Oberoi, Pranav, Wels, Winfried S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488744/
https://www.ncbi.nlm.nih.gov/pubmed/34599028
http://dx.doi.org/10.1136/jitc-2021-002980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488744/
https://www.ncbi.nlm.nih.gov/pubmed/34599028
http://dx.doi.org/10.1136/jitc-2021-002980

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