Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK)

Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown. In this study, we first described the anxious and...

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Detalles Bibliográficos
Autores principales: Herzog, David P., Perumal, Natarajan, Manicam, Caroline, Treccani, Giulia, Nadig, Jens, Rossmanith, Milena, Engelmann, Jan, Jene, Tanja, Hasch, Annika, van der Kooij, Michael A., Lieb, Klaus, Gassen, Nils C., Grus, Franz H., Müller, Marianne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488754/
https://www.ncbi.nlm.nih.gov/pubmed/34632008
http://dx.doi.org/10.1016/j.ynstr.2021.100404

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