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Lipid nanostructures for targeting brain cancer
Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these nanopart...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488847/ https://www.ncbi.nlm.nih.gov/pubmed/34632135 http://dx.doi.org/10.1016/j.heliyon.2021.e07994 |
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author | Nsairat, Hamdi Khater, Dima Odeh, Fadwa Al-Adaileh, Fedaa Al-Taher, Suma Jaber, Areej M. Alshaer, Walhan Al Bawab, Abeer Mubarak, Mohammad S. |
author_facet | Nsairat, Hamdi Khater, Dima Odeh, Fadwa Al-Adaileh, Fedaa Al-Taher, Suma Jaber, Areej M. Alshaer, Walhan Al Bawab, Abeer Mubarak, Mohammad S. |
author_sort | Nsairat, Hamdi |
collection | PubMed |
description | Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these nanoparticles. Nanoparticles are also considered as a major area of research and development to meet the essential requirements for use in nanomedicine where safety, compatibility, biodegradability, biodistribution, stability, and effectiveness are requirements towards the desired application. In this regard, lipids have been used in pharmaceuticals and medical formulations for a long time. The present work focuses on the use of lipid nanostructures to combat brain tumors. In addition, this review summarizes the literature pertaining to solid lipid nanoparticles (SLN) and nanostructured lipid carriers (LNC), methods of preparation and characterization, developments achieved to overcome blood brain barrier (BBB), and modifications used to increase their effectiveness. |
format | Online Article Text |
id | pubmed-8488847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84888472021-10-08 Lipid nanostructures for targeting brain cancer Nsairat, Hamdi Khater, Dima Odeh, Fadwa Al-Adaileh, Fedaa Al-Taher, Suma Jaber, Areej M. Alshaer, Walhan Al Bawab, Abeer Mubarak, Mohammad S. Heliyon Review Article Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these nanoparticles. Nanoparticles are also considered as a major area of research and development to meet the essential requirements for use in nanomedicine where safety, compatibility, biodegradability, biodistribution, stability, and effectiveness are requirements towards the desired application. In this regard, lipids have been used in pharmaceuticals and medical formulations for a long time. The present work focuses on the use of lipid nanostructures to combat brain tumors. In addition, this review summarizes the literature pertaining to solid lipid nanoparticles (SLN) and nanostructured lipid carriers (LNC), methods of preparation and characterization, developments achieved to overcome blood brain barrier (BBB), and modifications used to increase their effectiveness. Elsevier 2021-09-16 /pmc/articles/PMC8488847/ /pubmed/34632135 http://dx.doi.org/10.1016/j.heliyon.2021.e07994 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Nsairat, Hamdi Khater, Dima Odeh, Fadwa Al-Adaileh, Fedaa Al-Taher, Suma Jaber, Areej M. Alshaer, Walhan Al Bawab, Abeer Mubarak, Mohammad S. Lipid nanostructures for targeting brain cancer |
title | Lipid nanostructures for targeting brain cancer |
title_full | Lipid nanostructures for targeting brain cancer |
title_fullStr | Lipid nanostructures for targeting brain cancer |
title_full_unstemmed | Lipid nanostructures for targeting brain cancer |
title_short | Lipid nanostructures for targeting brain cancer |
title_sort | lipid nanostructures for targeting brain cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488847/ https://www.ncbi.nlm.nih.gov/pubmed/34632135 http://dx.doi.org/10.1016/j.heliyon.2021.e07994 |
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