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Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns

Clinical assessment of frontotemporal lobar degeneration (FTLD)/primary progressive aphasia (PPA) patients is challenging, given that common cognitive assessments rely extensively on language. Since asymmetry in neuroimaging biomarkers is often described as a central finding in these patients, our s...

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Autores principales: Franceschi, Ana M., Naser-Tavakolian, Kiyon, Clifton, Michael, Bangiyev, Lev, Cruciata, Giuseppe, Clouston, Sean, Franceschi, Dinko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488899/
https://www.ncbi.nlm.nih.gov/pubmed/34703399
http://dx.doi.org/10.4103/wjnm.wjnm_137_20
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author Franceschi, Ana M.
Naser-Tavakolian, Kiyon
Clifton, Michael
Bangiyev, Lev
Cruciata, Giuseppe
Clouston, Sean
Franceschi, Dinko
author_facet Franceschi, Ana M.
Naser-Tavakolian, Kiyon
Clifton, Michael
Bangiyev, Lev
Cruciata, Giuseppe
Clouston, Sean
Franceschi, Dinko
author_sort Franceschi, Ana M.
collection PubMed
description Clinical assessment of frontotemporal lobar degeneration (FTLD)/primary progressive aphasia (PPA) patients is challenging, given that common cognitive assessments rely extensively on language. Since asymmetry in neuroimaging biomarkers is often described as a central finding in these patients, our study evaluated [(18)F]-fluorodeoxyglucose (FDG) uptake patterns in patients meeting clinical and imaging criteria for FTLD, with emphasis on PPA. Fifty-one subjects underwent brain [(18)F]-FDG positron-emission tomography/magnetic resonance imaging (PET/MRI) as part of their routine clinical workup for dementia and neurodegenerative disease. Images were obtained using a Siemens Biograph mMR integrated 3T PET/MRI scanner. PET surface maps and fusion fluid-attenuated inversion recovery-PET images were generated utilizing MIMneuro software. Two board-certified neuroradiologists and one nuclear medicine physician blinded to patient history classified each FTLD/PPA subtype and assessed for left- versus right-side dominant hypometabolism. Qualitative and semiquantitative assessment demonstrated 18 cases of PPA, 16 behavioral variant frontotemporal dementia (bvFTD), 12 corticobasal degeneration, and 5 progressive supranuclear palsy. Among the 18 PPA subjects (11 svPPA, 5 lvPPA, and 2 agPPA), 12 (67%) demonstrated left-dominant hypometabolism and 6 (33%) right-dominant hypometabolism. While existing literature stresses left-dominant hypometabolism as a key imaging feature in the PPA subtypes, a third of our cases demonstrated right-dominant hypometabolism, suggesting that emphasis should be placed on the functionality of specific brain regions affected, rather than left versus right sidedness of hypometabolism patterns.
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spelling pubmed-84888992021-10-25 Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns Franceschi, Ana M. Naser-Tavakolian, Kiyon Clifton, Michael Bangiyev, Lev Cruciata, Giuseppe Clouston, Sean Franceschi, Dinko World J Nucl Med Original Article Clinical assessment of frontotemporal lobar degeneration (FTLD)/primary progressive aphasia (PPA) patients is challenging, given that common cognitive assessments rely extensively on language. Since asymmetry in neuroimaging biomarkers is often described as a central finding in these patients, our study evaluated [(18)F]-fluorodeoxyglucose (FDG) uptake patterns in patients meeting clinical and imaging criteria for FTLD, with emphasis on PPA. Fifty-one subjects underwent brain [(18)F]-FDG positron-emission tomography/magnetic resonance imaging (PET/MRI) as part of their routine clinical workup for dementia and neurodegenerative disease. Images were obtained using a Siemens Biograph mMR integrated 3T PET/MRI scanner. PET surface maps and fusion fluid-attenuated inversion recovery-PET images were generated utilizing MIMneuro software. Two board-certified neuroradiologists and one nuclear medicine physician blinded to patient history classified each FTLD/PPA subtype and assessed for left- versus right-side dominant hypometabolism. Qualitative and semiquantitative assessment demonstrated 18 cases of PPA, 16 behavioral variant frontotemporal dementia (bvFTD), 12 corticobasal degeneration, and 5 progressive supranuclear palsy. Among the 18 PPA subjects (11 svPPA, 5 lvPPA, and 2 agPPA), 12 (67%) demonstrated left-dominant hypometabolism and 6 (33%) right-dominant hypometabolism. While existing literature stresses left-dominant hypometabolism as a key imaging feature in the PPA subtypes, a third of our cases demonstrated right-dominant hypometabolism, suggesting that emphasis should be placed on the functionality of specific brain regions affected, rather than left versus right sidedness of hypometabolism patterns. Medknow Publications & Media Pvt Ltd 2021-05-26 /pmc/articles/PMC8488899/ /pubmed/34703399 http://dx.doi.org/10.4103/wjnm.wjnm_137_20 Text en Copyright: © 2021 World Journal of Nuclear Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Franceschi, Ana M.
Naser-Tavakolian, Kiyon
Clifton, Michael
Bangiyev, Lev
Cruciata, Giuseppe
Clouston, Sean
Franceschi, Dinko
Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns
title Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns
title_full Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns
title_fullStr Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns
title_full_unstemmed Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns
title_short Metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: Reassessment of expected [(18)F]-fluorodeoxyglucose uptake patterns
title_sort metabolic positron-emission tomography/magnetic resonance imaging in primary progressive aphasia and frontotemporal lobar degeneration subtypes: reassessment of expected [(18)f]-fluorodeoxyglucose uptake patterns
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488899/
https://www.ncbi.nlm.nih.gov/pubmed/34703399
http://dx.doi.org/10.4103/wjnm.wjnm_137_20
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