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The acid sphingomyelinase/ceramide system in COVID-19

Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry. Lowering the amount of ceramide or ceramide blockade due to inhibitors of ASM, gene...

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Detalles Bibliográficos
Autores principales:	Kornhuber, Johannes, Hoertel, Nicolas, Gulbins, Erich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488928/ https://www.ncbi.nlm.nih.gov/pubmed/34608263 http://dx.doi.org/10.1038/s41380-021-01309-5

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